CClinicalTrials.gg
Not yet recruitingNCT06706336ROMEUpdated Feb 11, 2026

Radon Asthma Intervention Trial

An interventional study of radon mitigation system and Sham (No Treatment) in Asthma, sponsored by Boston Children's Hospital. Not yet recruiting. Open to participants aged 5 Years to 25 Years. Per ClinicalTrials.gov, last updated 2026-02-11.

Sponsored by Boston Children's Hospital · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
180
Allocation
Randomized
Ages
5 Years to 25 Years
Sex
All
01

Study summary

To determine if radon mitigation can improve asthma

Read the detailed description

We will conduct a randomized, double-blind, sham controlled trial to investigate the efficacy of radon mitigation in the homes of susceptible individuals to provide evidence for health benefits by improving indoor air quality. The trial will include 180 children with asthma. We will install a standard radon specific mitigation system in the participant's home. Health outcomes will be followed over 48 weeks to determine the outcomes of the intervention versus inactive (sham) control.

02

Conditions studied

  • Asthma

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03

In context

Asthma

3,920 studies on the registry are indexed under Asthma; 506 are open to participants now.

This study's planned enrollment of 180 is above the median of 83 across 2,751 interventional studies indexed under Asthma.

Browse Asthma studies →

Lead sponsor

Boston Children's Hospital is the lead sponsor of 598 studies on the registry; 151 are open to participants now.

Of its 31 completed or terminated interventional studies of FDA-regulated products, 18 (58%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
5 Years to 25 Years
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

  1. Have physician-diagnosed asthma at least 1 year prior to the screening visit
  2. Have evidence of uncontrolled disease as defined by at least one of the following:

Use of an asthma medication during the prior 12 months, report of asthma symptoms over the prior 12 months (wheezing/whistling in the chest)(3)

OR

One or more asthma-related hospitalization, emergency room visit

OR

Unscheduled clinic or urgent care facility visit resulting in a burst of systemic steroids (3 days or more of prednisone or equivalent; 1 or more doses of dexamethasone) in the previous 12 months

Exclusion Criteria

  1. Not residing at the household for at least 5 days a week or family planning to move from the current home within the next twelve months, or homes with active radon mitigation systems (if home uses a HEPA filter air purifier, family must agree to disable the purifier for 28 days prior to randomization).
  2. Lung disease, other than asthma, that requires daily medication (inflammatory diseases, chronic lung diseases aside from asthma, congenital cardiopulmonary conditions requiring medication or surgical treatment),
  3. Homes with active HEPA filters will be excluded (even though the role of HEPA filters on radon and radon particles s is expected to be minimum and other exposures can be adjust for in the analysis)
  4. Cardiovascular disease that requires daily medication, excluding hypertension
  5. Taking a beta-blocker
  6. Currently receiving unstable level of Immunotherapy (allergy shots)
  7. Coordinator/PI judgment
  8. Inability to perform lung function testing
  9. Intake of abuse drugs or alcohol, have psychiatric disorders or severe mental disability that interferes with answering questions or following instructions.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
180 participants (estimated)

Study arms

  • Active comparator
    Active Radon Mitigation

    Active radon mitigation system

    Other: radon mitigation system

  • Sham comparator
    Inactive radon mitigation system control( sham)

    Inactive radon mitigation system looks and sounds like active but doesn't reduce radon ( sham)

    Other: Sham (No Treatment)

Interventions

  • Otherradon mitigation system

    standard radon mitigation system used to reduce radon in homes

  • OtherSham (No Treatment)

    inactive radon mitigation system

06

What researchers measure

Primary outcomes

  1. Asthma symptoms

    Number of Days With Asthma Symptoms

    Time frame: past 2 weeks

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 11, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06706336
Lead sponsor
Boston Children's Hospital
Responsible party
Wanda Phipatanakul (S Jean Emans, MD Professor of Pediatrics, Boston Children's Hospital) — Principal investigator
First posted
Nov 26, 2024
Start date
Jun 1, 2026 (estimated)
Primary completion
Dec 1, 2029 (estimated)
Completion
Apr 1, 2030 (estimated)
Last update
Feb 11, 2026

Study contacts

Wanda Phipatanakul
Contact
Asthma@childrens.harvard.edu
857-218-5336
Wanda Phipatanakul
principal investigator · Boston Children's Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.

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