An observational study in Osteoarthritis (OA) of the Knee, Fracture and Rheumatoid Arthritis, sponsored by LinkBio Corp.. Enrolling by invitation at 2 sites in United States. Open to participants aged 18 Years to 79 Years. Per ClinicalTrials.gov, last updated 2026-09-03.
Sponsored by LinkBio Corp. · Observational
To collect information about implant performance and patient clinical outcomes in patients undergoing primary total knee arthroplasty with the LinkSymphoKnee total knee replacement system with ultra-congruent tibial bearing surface.
The study will collect outcomes data on up to 600 patients from up to 3 sites using a legally marketed device according to its labeled intended use.
The study will collect:
Radiographic evaluations will be done through postoperative year 2. Other outcomes will be evaluated up to postoperative year 5.
2,974 studies on the registry are indexed under Osteoarthritis; 438 are open to participants now.
This study's planned enrollment of 600 is above the median of 100 across 601 observational studies indexed under Osteoarthritis.
Browse Osteoarthritis studies →This is the only study on the registry with LinkBio Corp. as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Patients seeking primary total knee arthroplasty from the participating surgeon investigators
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
total knee arthroplasty device with ultracongruent bearing surface
Knee Injury and Osteoarthritis Outcome Score - Joint Replacement (KOOS-JR) - change from baseline
Patient-reported outcome measure (PROM) that assesses knee health based on questions about pain, stiffness, function, and daily activities. Minimum score = 0. Maximum score = 100. Higher score means a better outcome.
Time frame: 1 year postoperative
Revision rate
Evaluates how often patients require additional surgery to remove or replace the knee arthroplasty device components.
Time frame: 5 years postoperative
Knee Society Score - change from baseline
A rating scale that measures the outcome of a patient's knee replacement surgery by assessing objective and subjective outcomes, including pain, range of motion, stability, walking distance, and ability to climb stairs, and also patient satisfaction and expectations. Minimum score = 0. Maximum score = 100. Higher score means better outcome.
Time frame: postoperative intervals through 5 years
PROMIS Global Health Score - change from baseline
PROMIS Global Health measures physical function, pain, fatigue, emotional distress, and social health. The raw score minimum is 7 and maximum is 35. Higher score means better outcome.
Time frame: postoperative intervals through 5 years
Surgery Satisfaction Score
Measures a patient's satisfaction with a surgical procedure based on questions about pain control and daily activities. Minimum score is 0. Maximum score is 10. Higher score means better outcome.
Time frame: 1 and 5 years postoperative
Forgotten Joint Score
Measures a patient's awareness of their artificial knee joint. Minimum score is 0. Maximum score is 100. Higher score means better outcome.
Time frame: postoperative intervals through 5 years
Knee Society Roentgenographic Evaluation and Scoring System
Evaluates radiographic signs of device stability. 3 zones are assigned to evaluate the patella component. 5-7 zones are assigned to evaluate the tibia and femur components. Radiolucencies are evaluated for size, location, and progression over time. Changes in implant position and/or radiolucencies that are large, continuous, or progressive over time signify possible or impending implant failure.
Time frame: Through 2 years postoperative
PROMIS Pain Interference Score - change from baseline
The score measures how pain affects a person's life. The raw score minimum is 6 and maximum is 30. A lower score means a better outcome.
Time frame: postoperative intervals through 5 years
PROMIS Physical Function Score - change from baseline
The score measures a person's ability to perform activities. The raw score minimum is 11 and maximum is 72.5. A higher score means a better outcome.
Time frame: postoperative intervals through 5 years
Plan to share: No
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