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RecruitingNCT06669884Updated Nov 12, 2024

Use of Determine Learning-based Cardiodynamicsgram (CDG) for Rapid and Precise Stratification of Chest Pain in Emergency Department

An observational study in Chest Pain and Acute Coronary Syndrome, sponsored by Qilu Hospital of Shandong University. Recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-11-12.

Sponsored by Qilu Hospital of Shandong University · Observational

From the registry’s dates

  • Started Oct 2021; still recruiting 4 years 11 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
8,000
Ages
18 Years and older
Sex
All
01

Study summary

Chest pain accounts for 10-20 percent of all emergency department visits. The stratification of chest pain is always a challenge. Electrocardiograms (ECG) have been used in clinical practice for 100 years, which is too important to be replaced due to its advantages of non-invasive, simple, rapid and inexpensive. ECG contains numerous signals derived from depolarization and repolarization of cardiomyocytes. However, the interpretation of ECG hasn't improved much in a hundred years. Based on determine-learning, Cong W's team developed an technique called "cardiodynamicsgram (CDG)", which is an outstanding method to identify myocardial ischemia. This study will further investigate the accuracy of CDG in stratification of patients with chest pain in Emergency department.

02

Conditions studied

  • Chest Pain
  • Acute Coronary Syndrome
03

In context

Acute Coronary Syndrome

1,461 studies on the registry are indexed under Acute Coronary Syndrome; 267 are open to participants now.

This study's planned enrollment of 8,000 is above the median of 500 across 561 observational studies indexed under Acute Coronary Syndrome.

Browse Acute Coronary Syndrome studies →

Lead sponsor

Qilu Hospital of Shandong University is the lead sponsor of 299 studies on the registry; 181 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

patients who suffers from acute chest pain suspected with acute coronary syndrome (ACS)

Inclusion criteria

  • aged 18 years or older
  • Those with suspected ACS who have symptoms of acute chest pain, visiting in the emergency department

Exclusion criteria

Exclusion Criteria:

  • Those who diagnosed with ST-segment elevation myocardial infarction (STEMI)
  • Those with hemodynamic instability (cardiogenic shock, cardiac arrest)
  • Those with malignant arrhythmias(ventricular tachycardia, ventricular fibrillation, third-degree atrioventricular block)
  • Those with aortic coarctation, or acute pulmonary embolism
  • Those who has an unanalysable ECG report due to loosened leads, unstable baseline, or signal interference, etc.
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
8,000 participants (estimated)
Patient registry
No

Groups and cohorts

  • machine learning algorithm

    machine learning algorithm based on ECG features

    Other: Cardiodynamicsgram (CDG)

Interventions

  • OtherCardiodynamicsgram (CDG)

    Cardiodynamicsgram (CDG) technique

06

What researchers measure

Primary outcomes

  1. The efficacy of CDG in the risk stratification of patients who have symptoms of acute chest pain suspected with acute coronary syndrome (ACS)

    Establishing an algorithm model of CDG in risk stratification in chest pain patients, the efficacy of the model was assessed by sensitivity, specificity, accuracy, positive predictive value, negative predictive value, and AUC, etc.

    Time frame: from the date of enrollment until the date of discharge, up to 30 days

07

Study locations

1 of 1 sites recruiting
  • Qilu Hospital of Shandong University
    Jinan, Shandong 250012, China
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 12, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06669884
Lead sponsor
Qilu Hospital of Shandong University
Responsible party
Sponsor
First posted
Nov 1, 2024
Start date
Oct 28, 2021
Primary completion
Sep 30, 2024
Completion
Oct 31, 2024 (estimated)
Last update
Nov 12, 2024

Study contacts

Jiaojiao Pang, Doctor
Contact
jiaojiaopang@126.com
0086-0531-82165674
Yuguo Chen, Professor
principal investigator · Qliu Hospital of Shandong University

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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