An interventional study of DW-MRI in Pregnancy in Diabetic and Placenta Diseases, sponsored by Hillel Yaffe Medical Center. Recruiting at 1 site in Israel. Open to female participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-24.
Sponsored by Hillel Yaffe Medical Center · Not applicable, Interventional, and Diagnostic
DW-MRI Allows a quantitative comparison of diffusion as an expression of tissue hypoxia. The investigators aim is to compare changes in placental diffusion in pregnant women with uncontrolled diabetes compared to healthy pregnant women using DW-MRI.
The investigators hypothesize that placentas of diabetic mothers will show lower diffusion / perfusion compared to placentas of healthy women.
In highly uncontrolled diabetes there is an increased risk of intrauterine fetal death. The mechanism of fetal death is unknown and unpredictable. One of the theories points to hypoxia as a precursor to the death of the fetus in the womb. If the researchers succeed in predicting changes in the placenta with the help of MRI, it may be possible to understand the mechanism of fetal damage as well as in the future to develop a protocol for predicting pregnancies prone to fetal death in the womb.
Exclusion Criteria:
3Th trimester pregnant women with gestational diabetes mellitus
Diagnostic Test: DW-MRI
3Th trimester pregnant women with unknown diseases (low risk factors)
Diagnostic Test: DW-MRI
Predict changes in ovarian diffusion using DW-MRI scan
Placental diffusion coefficient (D) measured by IVIM-DWI
Placental diffusion coefficient (D, mm²/s) derived from intravoxel incoherent motion diffusion-weighted MRI (IVIM-DWI). Mean D values will be extracted from whole-placenta regions of interest and compared between parturients with poorly controlled diabetes and excessive fetal growth and low-risk parturients with appropriately grown fetuses.
Time frame: Two years
Placental perfusion fraction (f) measured by IVIM-DWI
Placental perfusion fraction (f, unitless) derived from intravoxel incoherent motion diffusion-weighted MRI (IVIM-DWI). Mean f values will be extracted from whole-placenta regions of interest and compared between parturients with poorly controlled diabetes and excessive fetal growth and low-risk parturients with appropriately grown fetuses
Time frame: Two years
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Hillel Yaffe Medical Center