ClinicalTrials.gg
SuspendedNCT06638619Updated Sep 25, 2026

Comparative Efficacy of Saccadic and Biofeedback Training in Homonymous Hemianopia

An interventional study of Biofeedback Fixation Training and Saccadic Reading Training in Hemianopia, Homonymous, sponsored by University of Alabama at Birmingham. Suspended at 1 site in United States. Open to participants aged 18 Years to 89 Years. Per ClinicalTrials.gov, last updated 2026-09-25.

Sponsored by University of Alabama at Birmingham · Not applicable, Interventional, and Treatment

Why this study was suspended
funding
Updated Sep 25, 2026Now SuspendedFirst site in United States+4 moreGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
20
Allocation
Randomized
Ages
18 Years to 89 Years
Sex
All
01

Study summary

This pilot study aims to understand how eye movements change in people with vision loss from stroke after completing one of two types of training. The study will look at how eye movements and reading performance change after training. Researchers will compare the results of two groups: one group will complete five clinical training sessions using an eye-tracking machine for 30 minutes each, while the other group will do at-home reading exercises for 20 minutes a day, 5 days a week, for 6 weeks. The goal is to see if there is a difference in performance between the two types of training.

02

Conditions studied

  • Hemianopia, Homonymous

Keywords

  • stroke
  • vision
  • hemianopia
03

In context

Hemianopsia

63 studies on the registry are indexed under Hemianopsia; 24 are open to participants now.

This study's planned enrollment of 20 is below the median of 32 across 53 interventional studies indexed under Hemianopsia.

Browse Hemianopsia studies →

Lead sponsor

University of Alabama at Birmingham is the lead sponsor of 1,421 studies on the registry; 277 are open to participants now.

Of its 164 completed or terminated interventional studies of FDA-regulated products, 130 (79%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 89 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Diagnosis of stroke
  • Presence of hemianopia with central vision involvement
  • Stroke occurred at least 6-months before enrollment

Exclusion criteria

Exclusion Criteria:

  • Presence of hemianopia with macular sparing
  • Diagnosis of hemispatial neglect
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
20 participants (estimated)

Study arms

  • Experimental
    Biofeedback Fixation Arm

    Biofeedback training is a mind-body therapy that helps people learn to control their involuntary bodily functions, such as eye movements. The goal is to improve eye movement control to improve gaze stability.

    Behavioral: Biofeedback Fixation Training

  • Active comparator
    Saccadic Reading Arm

    Saccadic reading training helps people to learn to control their involuntary eye movements. The goal is to improve eye movement control to improve saccadic and fixational behaviors during reading activities.

    Behavioral: Saccadic Reading Training

Interventions

  • BehavioralBiofeedback Fixation Training

    This training type involves the use of microperimetry. Microperimetry is a visual field test that incorporates perimetry and retinal imaging and is a standard ophthalmic clinical technology. It allows for direct observation of the fundus, but uses an eye-tracking system to compensate for involuntary eye movements. A program designed to train patients to direct and hold their gaze at an eccentric location programmed by the controller will be used. When the participant directs their gaze towards the pre-programmed location, a sound of increasing frequency is emitted to let them know they are approaching the correct location. The sound stabilizes into a solid tone when the patient is gazing directly at the trained location (biofeedback) and they are asked to attempt to hold their gaze at this location for as long as possible.

  • BehavioralSaccadic Reading Training

    Participants will be assigned to participate in an at-home reading program. The reading exercises consist of worksheets with letter and number combinations of increasing complexity and font sizes. They are intended to increase accuracy in identifying letters and numbers. Worksheets will initially be dispensed with larger font type and spacing and be graded at weekly intervals towards regular, newspaper-size print and spacing over the course of training.

06

What researchers measure

Primary outcomes

  1. Oculomotor Metrics

    Participants will be asked to read aloud a series of sentences presented on a display. Eye movements will be recorded in real-time using an Eye-Link 1000 infrared eye-tracking camera, as the patient is reading what is on the display. The primary outcome measure will be the first saccade landing location.

    Time frame: Pre-training and at 6-weeks.

Secondary outcomes

  1. Pepper Visual Skills Reading Test (VSRST)

    A clinical reading assessment used in low vision settings to assess for common patterns of reading errors (misidentifications, skipped letters or words, skipped lines). The participant reads aloud lines of text (random letters and words of increasing complexity and decreasing line spacing.

    Time frame: Pre-training and at 6-weeks.

07

Study locations

1 site
  • Callahan Eye Hospital
    Birmingham, Alabama 35233, United States
08

Updates

1 registry update since Sep 25, 2026
Status
Not yet recruiting→Suspended funding
changed Sep 25, 2026
Sites
1 site added — first site in United States
Show site
  • Callahan Eye Hospital · Birmingham, United States
Sep 25, 2026
Start date
Jun 2026→Jun 2027
Sep 25, 2026
Primary completion
Dec 2026→Dec 2027
Sep 25, 2026
Study completion
Dec 2026→Dec 2027
Sep 25, 2026
Show all 1 update
  1. Sep 25, 2026
    Not yet recruiting→Suspended
    Why stopped funding
    1 site added — first site in United States
    Show site
    • Callahan Eye Hospital · Birmingham, United States
    Start date Jun 2026→Jun 2027
    Primary completion Dec 2026→Dec 2027
    Study completion Dec 2026→Dec 2027
    + 2 other changes: verification date and contact details

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

09

Registry details

Key details

Study ID
NCT06638619
Responsible party
Jason Eugene Vice (Assistant Professor, University of Alabama at Birmingham) — Principal investigator
First posted
Oct 15, 2024
Start date
Jun 2027 (estimated)
Primary completion
Dec 2027 (estimated)
Completion
Dec 2027 (estimated)
Last update
Sep 25, 2026

Study contacts

Jason Vice, Ph.D.
principal investigator · University of Alabama at Birmingham

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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