An interventional study of Light Intervention and Digital Intervention in Myopia, Light; Therapy, Complications and Myopia Progression, sponsored by National University of Singapore. Recruiting at 5 sites in Singapore. Open to participants aged 7 Years to 10 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-09-23.
Sponsored by National University of Singapore · Not applicable, Interventional, and Prevention
The goal of this clinical trial is to evaluate whether the optimization of daily exposure to light in primary school children can lead to better myopia prevention and control. The trial also aims to better understand the impact of light exposure on sleep and cognitive performance in children.
This trial has 3 arms namely, (1) a technical intervention arm, (2) a digital intervention arm, and (3) a control arm.
Participants will:
The primary objective of the study is to evaluate whether the optimization of daily exposure to light in primary school children can lead to better myopia prevention and control. To do so, we will evaluate the effectiveness, safety and feasibility of:
Arm 2: digital intervention which involves optimization of daily light exposure using an individualised behaviour-changing smart-phone application (Interventional LightUP application) coupled with child-worn light and activity sensors to provide parents with an individually tailored recommendation to adapt their children's behaviour and provide them with the required amounts of myopia-preventive light quantum/day. + standard classroom lighting
As compared to:
Our study will also lead to the following scalable and implementable outcomes:
A secondary objective of this study is to better understand the impact of light exposure on sleep and cognitive performance in children. This will be achieved through continuous wrist actigraphy monitoring and through cognitive assessments, performed in classrooms, using tablets (one tablet/child). The assessment consists of validated, child-adapted, higher cognitive tasks testing the following constructs: impulse control, spatial working memory, content working memory, cognitive flexibility, reaction time, and processing speed.
1,159 studies on the registry are indexed under Myopia; 225 are open to participants now.
This study's planned enrollment of 396 is above the median of 78 across 923 interventional studies indexed under Myopia.
Browse Myopia studies →National University of Singapore is the lead sponsor of 212 studies on the registry; 54 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Subject must meet all the inclusion criteria below to participate in this study.
Exclusion Criteria:
All subjects meeting any of the exclusion criteria at baseline will be excluded from participation.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Technical refinement of classroom lighting + Sham LightUP phone application (s-LightUP)
Other: Light Intervention
Standard classroom lighting + Interventional LightUP phone application (i-LightUP)
Behavioral: Digital Intervention
Standard care or control group which involves standard classroom lighting + Sham LightUP app (s-LightUP).
Other: Control Group
LEDs mimicking the spectrum of sunlight (4000K) administered daily for 1 academic year, every school day, for the entire school day. The light levels generated by these LEDs will fluctuate throughout the day but will remain under 1000 lux.
Smart-phone application (LightUP) will be synced daily to a child-worn light and activity sensor and will allow parents to track their children's outdoor time and exposure to brighter light levels across the day. The application will also nudge parents to increase their child's exposure to light (e.g., increase time outdoors, or sitting next to a window indoors) after school hours for better myopia prevention and control. i-LightUP aims to gradually assist parents in helping their children reach the ultimate goal of spending at least 2 hours per day in brighter light conditions (e.g., above 1000 lux).
Standard Classroom Lighting + Sham LightUP phone application
Cycloplegic auto-refraction
Measured using autoref/kerato/pachy/tonometer
Time frame: 1 year, once every 6 months (Baseline, Month 6, Month 12 Visit)
Axial Length
Measured using non-contact optical biometer
Time frame: 1 year, once every 6 months (Baseline, Month 6, Month 12 Visit)
Choroidal Thickness
Measured using optical coherence tomography (OCT) scan
Time frame: 1 year, once every 6 months (Baseline, Month 6, Month 12 Visit)
Retinal and choroidal perfusion
Measured using optical coherence tomography angiography (OCT-A) function within OCT machine used to measure choroidal thickness.
Time frame: 1 year, once every 6 months (Baseline, Month 6, Month 12 Visit)
Corneal Curvature
Measured using autoref/kerato/pachy/tonometer.
Time frame: 1 year, once every 6 months (Baseline, Month 6, Month 12 Visit)
Corneal Thickness
Measured using autoref/kerato/pachy/tonometer.
Time frame: 1 year, once every 6 months (Baseline, Month 6, Month 12 Visit)
Impulse control
Impulse control will be assessed using a validated, child-adapted task developed by collaborator Dr. Evelyn Law (NUS). The "Day and Night Cards" task or a similar task will be administered on tablets (one tablet per child). Impulse control will be quantified by the number of errors committed by the children during the task which involves shifting instructions and paradigms.
Time frame: 1 year, once every 3 months (Baseline, Month 3, Month 6, Month 9 , Month 12 Visit)
Cognitive flexibility
Cognitive flexibility will be assessed using a validated, child-adapted task developed by collaborator Dr. Evelyn Law (NUS). The "Day and Night Cards" task or a similar task will be administered on tablets (one tablet per child). Cognitive flexibility will be quantified by the number of errors committed by the children during the task which involves shifting instructions and paradigms.
Time frame: 1 year, once every 3 months (Baseline, Month 3, Month 6, Month 9 , Month 12 Visit)
Spatial working memory
Spatial working memory will be assessed using a validated, child-adapted task developed by collaborator Dr. Evelyn Law (NUS). The "Eight Boxes" task or a similar task will be administered on tablets (one tablet per child). Spatial working memory will be quantified by the number of errors committed by the children during the task.
Time frame: 1 year, once every 3 months (Baseline, Month 3, Month 6, Month 9 , Month 12 Visit)
Content working memory
Content working memory will also be assessed using a validated, child-adapted task developed by collaborator Dr. Evelyn Law (NUS). The "Eight Boxes" task or a similar task will be administered on tablets (one tablet per child). Content working memory will be quantified by the number of errors committed by the children during the task when remembering the content of different items in the task (e.g., strawberry, watermelon, etc.).
Time frame: 1 year, once every 3 months (Baseline, Month 3, Month 6, Month 9 , Month 12 Visit)
Processing speed
Processing speed will be assessed from the previous cognitive tasks (e.g., Eight Boxes and Day and Night Cards" through the investigation of reaction time (ms) in response to the content of the tasks. The tasks will be administered on tablets (one tablet per child).
Time frame: 1 year, once every 3 months (Baseline, Month 3, Month 6, Month 9 , Month 12 Visit)
Sleep quantity
This is a secondary outcome and will depend on the days of wear of the activity and light trackers. Night time sleep quantity (minutes) will be collected through actigraphy watches given to participants.
Time frame: 1 year or at least 1 week per month for 1 year
Sleep efficiency
This is a secondary outcome and will depend on the days of wear of the activity and light trackers. Night time sleep efficiency (%) calculated as the amount of time spent asleep (in minutes) by the total amount of time in bed (in minutes) will be measured using actigraphy watches given to participants.
Time frame: 1 year or at least 1 week per month for 1 year
Height
Height of the participant in cm
Time frame: 1 year, at baseline and 12 months from baseline
Weight
Weight of the participant in Kg
Time frame: 1 year, at baseline and 12 months from baseline
Visual acuity
LogMAR visual acuity test
Time frame: 1 year, once every 6 months (Baseline, Month 6, Month 12 Visit)
Daytime average light levels (lux)
Daytime average light levels (lux) collected using wearable light sensors.
Time frame: 1 year or at least 1 week per month for 1 year
Daytime average melanopic lux
Daytime average melanopic lux collected using wearable light sensors.
Time frame: 1 year or at least 1 week per month for 1 year
Time spent outdoors (questionnaires)
Estimated time spent outdoors collected using questionnaires
Time frame: 1 year or at least 1 week per month for 1 year
Time spent outdoors (wearables)
Calculated time spent outdoors collected using the wearable light sensors.
Time frame: 1 year or at least 1 week per month for 1 year
Color vision
Color vision assessment using the Ishihara color vision test
Time frame: Baseline
Cover test (distance and near)
Cover test to screen for strabismus
Time frame: 1 year, repeated every 6 months
Plan to share: No
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