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CompletedNCT06619756Updated Nov 12, 2025

Anomia Treatment Predictors

An interventional study of Phonomotor Treatment (PMT) and Phonological Components Analysis (PCA) in Anomia (Word-Finding Impairment) and Aphasia, sponsored by State University of New York at Buffalo. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-11-12.

Sponsored by State University of New York at Buffalo · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
2
Allocation
Randomized
Ages
18 Years and older
Sex
All
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Study summary

The goal of this clinical trial is to identify predictors of response to phonological-focused anomia treatment in people with aphasia. The main question it aims to answer is who responds to which type of anomia treatment. Researchers will compare Phonomotor Treatment and Phonological Components Analysis to see which treatment is more beneficial, and for whom. Participants will engage in both treatments over several months.

Read the detailed description

Participants will complete screening and characterization testing to determine eligibility for the study. Each treatment will be administered twice a week, for 10-15 sessions. Pre-treatment and post-treatment testing will also occur for each treatment. There will be a period of no treatment in between the first and second treatment blocks.

02

Conditions studied

  • Anomia (Word-Finding Impairment)
  • Aphasia

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Keywords

  • anomia treatment
  • aphasia treatment
03

In context

Anomia

47 studies on the registry are indexed under Anomia; 9 are open to participants now.

This study's enrollment of 2 is below the median of 24 across 43 interventional studies indexed under Anomia.

Browse Anomia studies →

Lead sponsor

State University of New York at Buffalo is the lead sponsor of 294 studies on the registry; 63 are open to participants now.

Of its 19 completed or terminated interventional studies of FDA-regulated products, 15 (79%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Chronic aphasia (6+ months)
  • Anomia
  • Sufficient auditory comprehension to follow task instructions
  • Phonologic impairment

Exclusion criteria

Exclusion Criteria:

  • Progressive neurological illness or disease, including dementia
  • Chronic medical illness that interferes with adherence to testing schedule
  • Severe, uncorrected vision or hearing impairment that interferes with task completion
  • Moderate-severe apraxia of speech or dysarthria that interferes with task completion
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
2 participants (actual)

Study arms

  • Experimental
    PMT

    Phonomotor Treatment (PMT) will be administered. This treatment improves anomia by training the sound sequences of words. This is a multimodal treatment approach that includes listening, producing, visualizing, and describing sounds and sound sequences. The participant practices the sound sequence tasks with the clinician.

    Behavioral: Phonomotor Treatment (PMT)

  • Experimental
    PCA

    Phonological Components Analysis (PCA) will be administered. This treatment improves anomia by identifying phonological features of words. A picture is presented. The participant provides features of the picture name: the first sound of the word, the final sound of the word, the number of syllables of the word, another word that starts with the same sound, and another words that rhymes with the word. The participant attempts to produce the word independently and by repeating after the clinician.

    Behavioral: Phonological Components Analysis (PCA)

Interventions

  • BehavioralPhonomotor Treatment (PMT)

    Anomia treatment focuses on improving word-finding abilities. This intervention targets the phonology of words to improve word-finding.

  • BehavioralPhonological Components Analysis (PCA)

    Anomia treatment focuses on improving word-finding abilities. This intervention targets the phonology of words to improve word-finding.

06

What researchers measure

Primary outcomes

  1. Naming of Trained Words

    Picture naming of trained words

    Time frame: Pre-treatment and Immediately post-treatment

Secondary outcomes

  1. Naming of Untrained Words

    Picture naming of untrained words

    Time frame: Pre-treatment and Immediately post-treatment

  2. Standardized Assessment of Phonology in Aphasia (SAPA)

    The SAPA assesses phonological processing abilities, including oral reading, rhyme judgments, minimal pair judgments, lexical decision, blending, and parsing.

    Time frame: Pre-treatment and Immediately post-treatment

  3. Philadelphia Naming Test

    The short-form of the Philadelphia Naming Test is a picture naming test of items not seen during treatment.

    Time frame: Pre-treatment and Immediately post-treatment

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Study locations

1 site
  • UB Audiology and Speech-Language Pathology Clinic
    Buffalo, New York 14214, United States
08

References and documents

Individual participant data

Plan to share: No — Sample size is low increasing risk of identification of individuals.

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Sep 2024 to primary completion in Oct 2025, 12 months.

Of 32 non-industry interventional studies with no phase under Anomia, half reached primary completion within 41 months of starting (the median), counting those still running; a quarter within 17 and three quarters within 62. This study's 12 months is below that.

Counting every sponsor, half of 32 studies reached it within 41 months; a quarter within 17 and three quarters within 62.

How these figures are worked out, and which studies are left out of them.

Registered
Sep 27, 2024
First posted
Oct 1, 2024
StartActual
Sep 18, 2024
Primary completionActual
Oct 1, 2025
CompletionActual
Oct 1, 2025
Last update
Nov 12, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Nov 12, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06619756
Responsible party
Nichol Castro (Assistant Professor, State University of New York at Buffalo) — Principal investigator
First posted
Oct 1, 2024
Start date
Sep 18, 2024
Primary completion
Oct 1, 2025
Completion
Oct 1, 2025
Last update
Nov 12, 2025

Study contacts

Nichol Castro, PhD
principal investigator · SUNY at Buffalo

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.

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