An observational study in Multiple Sclerosis (MS) - Relapsing-remitting, sponsored by University of Aarhus. Recruiting at 1 site in Denmark. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-10-09.
Sponsored by University of Aarhus · Observational
The goal of this case-control study is to investigate glucose brain metabolism in people with multiple sclerosis and age- and sex-matched healthy controls. The main questions it aims to answer are:
Participants will come in for testing lasting approximately three hours and undergo deuterium metabolic imaging, physical function test, cognitive function test, and answer survey.
3,460 studies on the registry are indexed under Multiple Sclerosis; 661 are open to participants now.
This study's planned enrollment of 20 is below the median of 100 across 1,016 observational studies indexed under Multiple Sclerosis.
Browse Multiple Sclerosis studies →University of Aarhus is the lead sponsor of 1,274 studies on the registry; 183 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The study seeks to include people with relapsing remitting multiple sclerosis that are otherwise healthy and age- and sex-matched healthy control participants.
Exclusion Criteria:
Pacemaker, neurostimulator or cholera implant. Metal foreign bodies such as fragments and irremovable piercings. Unsafe medical implants (safety of heart valves, hips and the like must be confirmed).
Claustrophobia. Largest circumference including arms > 160 cm
People with relapse remitting multiple sclerosis
Other: No Interventions
Healthy control participant who are age- and sex-matched to the MS group
Other: No Interventions
No delivered intervention.
lactate to glx ratio
Brain deuterium metabolic imaging determined lactate to glx ratio
Time frame: 2 hours from enrollment to end of assessment
Six-minute walk test
Measure of walking capacity as meters walking in six minutes
Time frame: 3 hours from enrollment to end of assessment
25 meter walk test
Maximal and usual walking speed over 25 feet including a 3 m measurement
Time frame: 3 hours from enrollment to end of assessment
Six-spot-step-test
Fastes time to kick six block away from six markings on the floor approximatly 1 meter from another in a zig-zag patteren.
Time frame: 3 hours from enrollment to end of assessment
Handgrip strength
Handgrip dynamometry
Time frame: 3 hours from enrollment to end of assessment
5-sit-to-stand
Time to perform five sit to stand.
Time frame: 3 hours from enrollment to end of assessment
Processing speed - Selective reminding test
Symbol digit modality test, number of symbols translated in 90 s
Time frame: 3 hours from enrollment to end of assessment
Memory function - Symbol digit modality test
Symbol digit modality test * Short term memory * consistence short term memory * long-term memory
Time frame: 3 hours from enrollment to end of assessment
Glukose level
From blood sample
Time frame: 3 hours from enrollment to end of assessment
Lactat level
From blood sample
Time frame: 3 hours from enrollment to end of assessment
Glucose uptake
Brain deuterium metabolic imaging demined glucose uptake measured by glucose to DHO + glucose ratio
Time frame: 2 hours from enrollment to end of assessment
glucose to glx ratio
Brain deuterium metabolic imaging demined glucose to glx ratio
Time frame: 2 hours from enrollment to end of assessment
Clinical information on multiple sclerosis - Disease modifying treatment
Information on current disease modifying treatment are exacted from the hospital patient record
Time frame: 7 days from enrollment to end of assessment
Clinical information on multiple sclerosis - Time since diagnosis
Information on time since diagnosis are exacted from the hospital patient record
Time frame: 7 days from enrollment to end of assessment
Modified Fatigue Impact Scale
A 29-item questionnaire measuring the impact of multiple sclerosis on the patient. With a minimum score of 29 and a maximum of 116, a higher score indicates a worse outcome.
Time frame: 7 days from enrollment to end of assessment
Clinical information on multiple sclerosis - Expanded disability status score
Information on expanded disability status score is exacted from the hospital patient record. The expanded disability status score is a physician rating of disease severity from 0-10 with a higher score indicating higher disability.
Time frame: 7 days from enrollment to end of assessment
Multiple Sclerosis Impact Scale
A 21-item questionnaire measuring the impact of multiple sclerosis on the patient. With a minimum score of 0 and a maximum of 84, a higher score indicates a worse outcome.
Time frame: 7 days from enrollment to end of assessment
Plan to share: No — Due to the European Unions General Data Protection Regulation.
No publications or documents are linked to this record.
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University of Aarhus