An observational study in Rheumatoid Arthritis and Periodontitis, sponsored by Zhibin Xu. Status unknown. Per ClinicalTrials.gov, last updated 2024-09-20.
Sponsored by Zhibin Xu · Observational
This study aims to investigate the causal relationship between rheumatoid arthritis and periodontitis using Mendelian randomization. Data will be sourced from genome-wide association studies (GWAS) to explore genetic associations and assess potential risk factors in an East Asian population.
The purpose of this study is to explore the causal association between rheumatoid arthritis (RA) and periodontitis using Mendelian randomization (MR). RA and periodontitis share similar inflammatory pathways and immune responses, but their causal relationship remains unclear. This study will utilize genome-wide association studies (GWAS) data from an East Asian population to identify single nucleotide polymorphisms (SNPs) associated with RA and assess their potential impact on the risk of developing periodontitis. Statistical methods such as inverse-variance weighting, MR-Egger regression, and weighted median analysis will be employed to analyze the data. The findings may provide insights into the shared genetic basis and causal relationships between these two conditions, offering potential targets for preventive strategies.
2,962 studies on the registry are indexed under Arthritis, Rheumatoid; 396 are open to participants now.
This study's planned enrollment of 220,000 is above the median of 176 across 854 observational studies indexed under Arthritis, Rheumatoid.
Browse Arthritis, Rheumatoid studies →Zhibin Xu is the lead sponsor of 5 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
This study utilizes genetic data from an East Asian population, sourced from publicly available genome-wide association studies (GWAS) focused on rheumatoid arthritis and periodontitis.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Causal Association Between Rheumatoid Arthritis and Periodontitis
This study uses Mendelian randomization to evaluate the causal relationship between rheumatoid arthritis (RA) and periodontitis in the East Asian population. The analysis utilizes genome-wide association study (GWAS) data, employing inverse variance weighting (IVW), weighted median, and MR-Egger regression methods to assess the genetic relationship and the risk contribution of RA to the development of periodontitis.
Time frame: Data collected from 2023 to 2024.
Analysis of Genetic Pleiotropy and Confounders
Evaluation of the presence of genetic pleiotropy and its potential effect on the association between rheumatoid arthritis and periodontitis.
Time frame: 2023 to 2024
No study locations are listed for this record.
Start is estimated for Oct 2024; primary completion for Nov 2024, 1 month later.
How these figures are worked out, and which studies are left out of them.
This study is status unknown, as verified in Sep 2024. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Zhibin Xu