CClinicalTrials.gg
CompletedNCT06523075Updated Oct 31, 2024

Host Dysregulation-Driven Sepsis Prediction Model

An observational study in Sepsis, sponsored by Second Affiliated Hospital of Wenzhou Medical University. Completed at 2 sites in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-10-31.

Sponsored by Second Affiliated Hospital of Wenzhou Medical University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
1,000
Ages
18 Years and older
Sex
All
01

Study summary

The aim of this study is to identify risk factors associated with sepsis and to construct a predictive model for sepsis. This will provide an objective theoretical and empirical foundation for the diagnosis, assessment, and management of sepsis in our country.The primary questions addressed are:

What are the risk factors for the development of sepsis? How do we improve the prognosis of sepsis?

02

Conditions studied

  • Sepsis

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03

In context

Sepsis

1,899 studies on the registry are indexed under Sepsis; 462 are open to participants now.

This study's enrollment of 1,000 is above the median of 160 across 931 observational studies indexed under Sepsis.

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Lead sponsor

Second Affiliated Hospital of Wenzhou Medical University is the lead sponsor of 133 studies on the registry; 44 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Sampling method
Probability sample

Study population

Patients with Infection or Suspected Infection

Inclusion criteria

  • Patients with Infection or Suspected Infection

Exclusion criteria

Exclusion Criteria:

  • Patients with Autoimmune Diseases
  • Pregnant Women
  • Patients with Advanced-Stage Cancer and Systemic Metastasis
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
1,000 participants (actual)
Patient registry
No

Groups and cohorts

  • Sepsis Group

    Other: Tumor Necrosis Factor · Other: Interleukin-1β · Other: Interleukin-12 · Other: Interleukin-18 · Other: Complement C3 · Other: Complement C5

  • Non-Sepsis Group

    Other: Tumor Necrosis Factor · Other: Interleukin-1β · Other: Interleukin-12 · Other: Interleukin-18 · Other: Complement C3 · Other: Complement C5

Interventions

  • OtherTumor Necrosis Factor

    This study is a retrospective observational study, with Tumor Necrosis Factor being one of the exposure factors under investigation.

  • OtherInterleukin-1β

    This study is a retrospective observational study, with Interleukin-1β being one of the exposure factors under investigation.

  • OtherInterleukin-12

    This study is a retrospective observational study, with Interleukin-12 being one of the exposure factors under investigation.

  • OtherInterleukin-18

    This study is a retrospective observational study, with Interleukin-18 being one of the exposure factors under investigation.

  • OtherComplement C3

    This study is a retrospective observational study, with Complement C3 being one of the exposure factors under investigation.

  • OtherComplement C5

    This study is a retrospective observational study, with Complement C5 being one of the exposure factors under investigation.

06

What researchers measure

Primary outcomes

  1. Sepsis

    A rapid increase of 2 or more points points in the Sequential Organ Failure Assessment (SOFA) score after patient infection.SOFA score, which ranges from a minimum of 2 to a maximum of 15, indicates a worse outcome with higher scores.

    Time frame: 3 months

07

Study locations

2 sites
  • Xiue Ye
    Wenzhou, Zhejiang 325000, China
  • The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,
    Wenzhou, Zhejiang 325027, China
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 31, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06523075
Lead sponsor
Second Affiliated Hospital of Wenzhou Medical University
Responsible party
Sponsor
First posted
Jul 26, 2024
Start date
Sep 1, 2024
Primary completion
Oct 13, 2024
Completion
Oct 17, 2024
Last update
Oct 31, 2024

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2024. You cannot join it, but the record below documents what was studied.

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