ClinicalTrials.gg
Status unknownNCT06481345CARPEDIEMUpdated Jul 1, 2024

Characterization of Myeloproliferative Neoplasia With a Mutated IDH, SRSF2 or SF3B1 Allele (CARPEDIEM)

An observational study in Myeloproliferative Disorders, sponsored by University Hospital, Brest. Status unknown at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-07-01.

Sponsored by University Hospital, Brest · Observational

The sponsor has not verified this record recently (last verified Apr 2024), so the status shown — last known as Active, not recruiting — may be out of date.
Study type
Observational
Model
Case-control
Time perspective
Retrospective
Enrollment
300
Ages
18 Years and older
Sex
All
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Study summary

Retrospective study assessing the impact of IDH1/2, SRSF2 or SF3B1 mutations on event free survival of MPN patients

Read the detailed description

Patients with a diagnosis of MPN and a mutation of IDH1/2, SRSF2 or SF3B1 will be included. Clinical and biological characterisation at diagnosis, as well as evlution will be recorded. Event free survival will be assessed in each group (event = thrombosis, transformation to mylofibrosis/acute leukemia, death).

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Conditions studied

  • Myeloproliferative Disorders
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In context

Myeloproliferative Disorders

640 studies on the registry are indexed under Myeloproliferative Disorders; 111 are open to participants now.

This study's planned enrollment of 300 is above the median of 143 across 113 observational studies indexed under Myeloproliferative Disorders.

Browse Myeloproliferative Disorders studies →

Lead sponsor

University Hospital, Brest is the lead sponsor of 601 studies on the registry; 136 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Sampling method
Non-probability sample

Study population

Patients followed by hematologists of the French Intergroup of MPN

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients with MPN diagnosis
  • Mutation in IDH1/2, SRSF2 or SF3B1

Exclusion criteria

Exclusion Criteria:

  • Unable to consent
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Study design

Observational model
Case-control
Time perspective
Retrospective
Enrollment
300 participants (estimated)
Patient registry
No

Groups and cohorts

  • MPN patients with IDH1/2 mutation
  • MPN patients with SRSF2 mutation
  • MPN patients with SF3B1 mutation
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What researchers measure

Primary outcomes

  1. Event free survival

    Time frame: 3 years

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Study locations

1 site
  • Chu Brest
    Brest, 29609, France
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References and documents

Individual participant data

Plan to share: Yes — All collected data that underlie results in a publication

Supporting information: Study protocol

Time frame: Data will be available beginning three years and ending fifteen years following the final study report completion

Access criteria: Data access requests will be reviewed by the internal committee of Brest UH. Requestors will be required to sign and complete a data access agreement

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 1, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06481345
Responsible party
Sponsor
First posted
Jul 1, 2024
Start date
Jun 25, 2024
Primary completion
May 31, 2026 (estimated)
Completion
May 31, 2026 (estimated)
Last update
Jul 1, 2024

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.

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Discussion

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