An interventional study of Testicular sperm extraction (TESE) and Ejaculate in Male Infertility, sponsored by Ganin Fertility Center. Completed at 1 site in Egypt. Per ClinicalTrials.gov, last updated 2025-08-15.
Sponsored by Ganin Fertility Center · Not applicable, Interventional, and Treatment
There is evidence indicating that sperm plays a role in determining blastocyst ploidy status. In our study, we aim to compare the outcomes of preimplantation genetic testing for aneuploidy (PGT-A) and the subsequent clinical outcomes following transfers of euploid embryos. This comparison will be conducted between cases where ejaculated sperm and cases where testicular sperm were used for intracytoplasmic sperm injection (ICSI), specifically focusing on severe male factor infertility patients.
265 studies on the registry are indexed under Infertility, Male; 62 are open to participants now.
This study's enrollment of 100 is above the median of 80 across 171 interventional studies indexed under Infertility, Male.
Browse Infertility, Male studies →Ganin Fertility Center is the lead sponsor of 15 studies on the registry; none are open to participants now.
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Exclusion Criteria:
Patients within this arm will undergo ICSI utilizing ejaculated sperm.
Other: Ejaculate
Patients within this arm will undergo ICSI utilizing testicular sperm.
Procedure: Testicular sperm extraction (TESE)
Surgical procedure used to retrieve sperm directly from the testicles of men who have low sperm production or no sperm in their ejaculate
Ejaculate processing for ICSI
Euploidy rate
Defined as the proportion of euploid blastocysts
Time frame: 15 days post ICSI
Aneuploidy rate
Defined as the proportion of aneuploid blastocysts
Time frame: 15 days post ICSI
Low mosaic rate
Defined as the proportion of low mosaic blastocysts
Time frame: Time Frame: 15 days post ICSI
High mosaic rate
Defined as the proportion of high mosaic blastocysts
Time frame: Time Frame: 15 days post ICSI
Implantation rate
defined as the percentage of successfully implanted embryos
Time frame: 6-9 weeks post-embryo transfer
Ongoing pregnancy rate
defined as a positive heartbeat on ultrasound beyond 12 weeks of gestation
Time frame: 12 weeks of gestation
Miscarriage rate
defined as pregnancy loss following confirmation of clinical pregnancy
Time frame: after 6 weeks of gestation
Clinical pregnancy rate
defined as the presence of a fetal heartbeat or gestational sac 6-9 weeks post-embryo transfer
Time frame: 6-9 weeks post-embryo transfer
Fertilization rate
Defined as the proportion of fertilizaed oocytes
Time frame: 1 day
Cleavage rate
Defined as the proportion of cleaved embryos on day 3
Time frame: 3 days
Blastocyst development rate
Defined as the proportion of blastocysts formed on day 5 or 6
Time frame: 5-6 days
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Jun 2024. You cannot join it, but the record below documents what was studied.
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