An interventional study of Saliva collection in Group A Streptococcal Infections, sponsored by The Hospital for Sick Children. Active, not recruiting at 2 sites in Canada. Open to participants aged 0 Years to 18 Years. Per ClinicalTrials.gov, last updated 2026-05-07.
Sponsored by The Hospital for Sick Children · Not applicable, Interventional, and Diagnostic
This study is being done to evaluate whether saliva can be used to diagnose GAS infection and also to compare different testing methods in the microbiology lab. The saliva sample testing will be compared to the throat swab testing to see if saliva testing works as well. The lab will also try different testing methods to see if a faster type of testing (e.g. molecular testing) works as well as the regular method, which takes 48 hours to get results.
This is important because throat swabs can be challenging to collect in some children, and saliva is often much easier and more acceptable by children to collect. This could improve our ability to accurately diagnose and treat GAS infections.
155 studies on the registry are indexed under Streptococcal Infections; 15 are open to participants now.
This study's planned enrollment of 200 is below the median of 250 across 105 interventional studies indexed under Streptococcal Infections.
Browse Streptococcal Infections studies →The Hospital for Sick Children is the lead sponsor of 568 studies on the registry; 81 are open to participants now.
Of its 7 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Self-collected saliva sample
Diagnostic Test: Saliva collection
Self-collected saliva sample with molecular testing performed. Results are compared to rapid antigen testing, bacterial throat culture and bacterial throat molecular testing
Rate and sensitivity of GAS detection
compare the rate and sensitivity of GAS detection by throat bacterial culture, throat molecular detection and saliva molecular detection according to a semi-quantitative value (quantified growth on bacterial culture or CT value for molecular assays)
Time frame: Within 24 hours of collection
Plan to share: No
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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The Hospital for Sick Children