An observational study in Acute Mesenteric Ischemia, sponsored by University of Tartu. Recruiting at 1 site in Estonia. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-03-25.
Sponsored by University of Tartu · Observational
Computed tomography (CT) is the standard modality for scanning patients with critical acute abdominal conditions, including suspected acute mesenteric ischemia (AMI). CT imaging can potentially differentiate between reversible and irreversible ischaemic damage of the bowel. This moment is pivotal in selecting the treatment strategy for AMI - in the absence of irreversible damage; reperfusion therapy can preserve intestinal viability, thereby avoiding the need for bowel resection. The present study tests the hypothesis that combining several symptoms may enhance the diagnostic performance of CT scanning in detecting salvageable bowel in patients with AMI. This study is an ancillary component of the AMESI study (Clinical Trials: NCT05218863) - a prospective, multicentre observational study aimed at identifying the incidence and describing the outcomes of acute mesenteric ischemia (AMI) in adult hospitalized patients. The ultimate purpose of the present study is to create a computed tomography-based radiological score for the assessment of bowel viability in patients with AMI.
This is a substudy of the AMESI study - "Incidence, Diagnosis, Management, and Outcome of Acute Mesenteric Ischaemia: A Prospective, Multicentre Observational Study." (Clinical Trials: NCT05218863) As of the end of August 2023, a total of 705 patients from 32 study sites worldwide have been enrolled, with 418 of them having confirmed cases of AMI. For patients with confirmed AMI, comprehensive data collection concerning diagnostics, management, and long-term outcomes has been completed
Exclusion Criteria:
Patients included in the AMESI study as suspected AMI
Patients included in the AMESI study with confirmed AMI, who did not undergo bowel resection Patients with one of the following: 1. treated endovascularly and did not undergo bowel resection secondarily 2. received surgical revascularization without bowel resection (initial or secondary) 3. received explorative laparoscopy or laparotomy without the need for bowel resection (initially or secondarily) 4. received conservative treatment without the need for secondary bowel resection
Patients included in the AMESI study with confirmed AMI who (one of the following): 1. underwent bowel resection initially 2. underwent bowel resection secondarily 3. did not undergo bowel resection because non-salvageable bowel 4. were changed to palliation due to the progression of ischaemia after any initial treatment with curative intention (including endovascular and conservative)
Frequency rate
Frequency rate of common radiological signs in AMI patients with and without salvageable bowel.
Time frame: up to one month
Performance of the radiological score
Performance of the radiological score in patients with different types of AMI.
Time frame: up to one month
Documents are hosted by the registry — open the source record to download them.
Plan to share: Undecided
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Tartu