A Phase 2 interventional study of Omega-3 Ethyl Esters 4 g and Omega-3 Ethyl Esters 2 g in Postoperative Delirium, sponsored by University of Missouri-Columbia. Terminated at 1 site in United States. Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2026-05-11.
Sponsored by University of Missouri-Columbia · Phase 2, Interventional, and Prevention
The purpose of this study is to determine whether giving omega-3 fatty acids prior to and after cardiac bypass surgeries decreases the incidence of postoperative delirium in patients aged 65 and over.
Patients aged 65 years and over requiring elective cardiac bypass surgeries will receive either 0, 2, or 4 grams of omega-3 ethyl esters before their surgery and for 3 days postoperatively to determine whether there is an affect on the incidence of postoperative delirium. All patients will receive hospital standard of care therapy for their surgery and hospital stay.
763 studies on the registry are indexed under Emergence Delirium; 241 are open to participants now.
This study's enrollment of 1 is below the median of 120 across 475 interventional studies indexed under Emergence Delirium.
Browse Emergence Delirium studies →University of Missouri-Columbia is the lead sponsor of 357 studies on the registry; 70 are open to participants now.
Of its 42 completed or terminated interventional studies of FDA-regulated products, 28 (67%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Patients will be given 4 grams of omega-3 ethyl esters orally before surgery and for 3 days postoperatively.
Drug: Omega-3 Ethyl Esters 4 g
Patients will be given 2 grams of omega-3 ethyl esters orally before surgery and for 3 days postoperatively.
Drug: Omega-3 Ethyl Esters 2 g
Patients will not receive any study drug.
4 grams = 4 capsules, once daily
Also known as: Omega-3 ethyl esters, Lovaza
2 grams = 2 capsules, once daily
Also known as: Lovaza, Omega-3 ethyl esters
Presence of Postoperative Delirium
Number of patients that experienced postoperative delirium during the study.
Time frame: From the date of surgery until the patient is discharged, up to 30 days.
Postoperative Delirium Symptoms
Presence of any postoperative delirium symptoms during patient's hospital stay.
Time frame: From the date of surgery until the patient is discharged, up to 30 days.
Length of Stay
Number of days patient stayed in hospital from the time of admission to discharge.
Time frame: From the date of surgery until the patient is discharged, up to 30 days.
Type of Anesthesia Used
Number of patients administered anesthesia using mainly propofol or sevoflurane.
Time frame: During surgery, up to 24 hours
Amount of Pain Medication Given Postoperatively
Average morphine milligram equivalents given to patients postoperatively until their discharge from the hospital.
Time frame: From the date of surgery until the patient is discharged, up to 30 days.
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University of Missouri-Columbia