An interventional study of Aerobic exercise, Strength training, Flexibility exercise in Breast Neoplasms, sponsored by Asan Medical Center. Recruiting at 1 site in South Korea. Open to female participants aged 20 Years to 80 Years. Per ClinicalTrials.gov, last updated 2025-06-29.
Sponsored by Asan Medical Center · Not applicable, Interventional, and Supportive care
Research purpose: Lymphedema is a very common complication in breast cancer patients. However, since there is currently no curable treatment, it is important to prevent and reduce the severity of lymphedema. The purpose of this study is to evaluate whether preoperative exercise is effective in preventing lymphedema after surgery. For secondary outcome, the preventive effects of exercise on other upper extremity dysfunctions (eg. pectoralis tightness, Axillary web syndrome, Adhesive capsulitis), which are common in breast cancer patients, were assessed.
Study subjects:
Result variable:
Primary outcome variable:
1) Incidence and severity of postoperative lymphedema: bilateral upper limb volume, ICG lymphography
Secondary outcome variables:
Assessment Schedule:
Number of study subjects:
12,544 studies on the registry are indexed under Breast Neoplasms; 2,892 are open to participants now.
This study's planned enrollment of 60 is below the median of 72 across 9,303 interventional studies indexed under Breast Neoplasms.
Browse Breast Neoplasms studies →Asan Medical Center is the lead sponsor of 562 studies on the registry; 71 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Individually tailored exercise consisting of aerobic, strength, and flexibility exercises is prescribed, self-exercise compliance monitoring through an application, and diet management education through nutritional counseling.
Behavioral: Aerobic exercise, Strength training, Flexibility exercise
One session of flexibility exercise education, diet management education through nutritional counseling
Aerobic exercise: 30-40 minutes/time, 3-5 times a week, intensity of 4-6 points on the Rating of Perceived Exertion(RPE) 10-point scale(A simple conversation is possible during exercise, but the intensity is such that you feel out of breath) Strength training: 2-3 times a week, 3 sets of 10 repetitions per movement * Upper extremities: Biceps brachii, triceps brachii, deltoid, pectoralis muscle exercise * Lower extremities: gluteus maximus, hamstrings, quadriceps exercise Flexibility exercise: Stretching and mobility exercises reflecting post-surgery rehabilitation
Bilateral upper limb volume
Using a tape measure, measure the circumference from the wrist to the armpit every 4cm, then apply the ΣCircumference2/π formula to calculate the volume of the upper limb.
Time frame: Immediately, Preoperatively, 1 month, 3 months, 6 months.
ICG lymphography
Indocyanine green (ICG) contrast agent is injected subcutaneously in the distal area, and lymph fluid flowing to the proximal area through collateral lymphatic vessels is checked with an infrared camera.
Time frame: Immediately, 1 month, 6 months.
Body composition
After attaching electrodes to both hands and feet using the Inbody S10 equipment, quantitatively evaluate body composition by measuring human body impedance using multiple frequencies.
Time frame: Immediately, 6 months.
Shoulder range of motion
Measurements are made according to a standardized protocol using a goniometer.
Time frame: Immediately, Preoperatively, 1 month, 3 months, 6 months.
Upper limb strength, grip strength
Using a digital hand held dynamometer, the strength of elbow flexion and extension, shoulder abduction, and flexor extensor muscles was measured. Measure grip strength using a digital hand held dynamometer
Time frame: Immediately, 6 months
EORTC QLQ-C30
Evaluate the patient's quality of life through the corresponding questionnaire
Time frame: Immediately, 6 months
EORTC QLQ-BR23
Evaluate the patient's quality of life through the corresponding questionnaire
Time frame: Immediately, 6 months
Plan to share: No
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