A Phase 3 interventional study of Amiloride in Hypertension Essential, Salt Excess and Genetic Hypertension, sponsored by Ospedale San Raffaele. Completed at 1 site in Italy. Open to male participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2024-05-16.
Sponsored by Ospedale San Raffaele · Phase 3, Interventional, and Other
The study is a non-pharmacological interventional, single-center, national, non-randomised, comparative and open label.
The study is carried out to evaluate primarily the difference in the activity of the renal transporter ENaC (through dosage of sodium) through its inhibition with a single dose of Amiloride in hypertensive patients characterized by the polymorphism of alpha Adducin rs496. It's also aimed to see the difference in potassium and the change in systolic and diastolic blood pressure after amiloride administration
6,689 studies on the registry are indexed under Hypertension; 965 are open to participants now.
This study's enrollment of 40 is below the median of 90 across 4,995 interventional studies indexed under Hypertension.
Browse Hypertension studies →Ospedale San Raffaele is the lead sponsor of 46 studies on the registry; 15 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
known causes of secondary hypertension;
The protocol involves a test of oral administration of a single dose of Amiloride (5 or 10 mg based on body weight) to 20 patients carrying the wild-type (GG) genotype of ADD1 rs4961
Drug: Amiloride
The test involves the administration of a single dose of 5 or 10 mg of Amiloride to 20 hypertensive carriers of the T variant (GT or TT)
Drug: Amiloride
administration of a single dose of 5 or 10 mg of Amiloride (based on body weight) After oral intake of the drug, the increase in sodium in the urine ends within 8 hours
Evaluate urinary sodium
Evaluation of sodium levels after oral administration of Amiloride
Time frame: 3 hrs and 6 hrs
Evaluate potassium levels
Evaluation of potassium plasma levels after oral administration of Amiloride
Time frame: 3 hrs and 6 hrs
Evaluation of systolic blood pressure
Evaluation of systolic blood pressure after oral administration of Amiloride
Time frame: 3 hrs and 6 hrs
Evaluation of diastolic blood pressure
Evaluation of diastolic blood pressure after oral administration of Amiloride
Time frame: 3 hrs and 6 hrs
This study is completed, as verified in May 2024. You cannot join it, but the record below documents what was studied.
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Ospedale San Raffaele