An observational study in IIH - Idiopathic Intracranial Hypertension, sponsored by Assiut University. Not yet recruiting. Open to participants aged 16 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-04-09.
Sponsored by Assiut University · Observational
Aim of the study :
Idiopathic intracranial hypertension (IIH) is caused by an elevation of intracranial pressure (ICP). The condition mainly affects obese young women of childbearing age.
In a recent study in the United Kingdom University of Kentucky urokinase, the estimated annual incidence was 4.7 % which represents a growth of 108% in 14 years, and parallels the growth of obesity prevalence .
The combination of raised intracranial pressure, without hydrocephalus or mass lesion, normal cerebrospinal fluid (CSF) composition and where no underlying aetiology is found are accepted criteria for the diagnosis of IIH.
The two most prominent symptoms of IIH are progressive visual deterioration and chronic headache, although additional symptoms including cranial nerve palsies, cognitive deficits, tinnitus and olfactory dysfunction are frequently also part of the clinical presentation. While the visual dysfunction is known to largely result from a pressure-induced papilledema, the origin of the IIH-related headache is less clear and therapeutic approaches are less investigated.
The conventional treatment for IIH involves weight loss, steroids, diuretics, and serial lumbar punctures and surgical treatment.
Surgical intervention should be conducted as soon as medical treatment fails. It is not acceptable to delay the intervention for patient with sever visual deterioration . Therefore surgery is indicated once visual loss continues despite optimum medical therapy .
Medical treatment with acetazolamide and serial lumbar punctures represent the initial management, in such cases preserving surgery to non-responding cases and those who cannot tolerate medical treatment.
Surgical treatment include lumboperitoneal shunt insertion , navigation guided ventriculo-peritoneal shunt ,endovascular stenting of sinuses in cases of sinus thrombosis and stenosis .
185 studies on the registry are indexed under Intracranial Hypertension; 45 are open to participants now.
This study's planned enrollment of 64 is close to the median of 60 across 80 observational studies indexed under Intracranial Hypertension.
Browse Intracranial Hypertension studies →Assiut University is the lead sponsor of 4,901 studies on the registry; 2,098 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Patients have symptoms of increased intracranial hypertension presenting to Assiut University hospital
patient has symptoms of increased intracranial pressure with :-
Exclusion Criteria:
Any patient diagnosed with increased intracranial pressure due to:
Medical treatment Lumbar puncture Theco peritoneal shunt
Also known as: Theco peritoneal shunt
Patient improvement regarding headache, visual symptoms
Determine the Severity of headache on scale from (0-10) ((0-4)\>mild, (5-7)\>moderate, (8-10)\>sever)
Time frame: 1 year
Patients improvement regarding fundus examination during regular visual assessment
Fundus examination grading (1-2-3-4)
Time frame: 1 year
Complication
Complication of each treatment option
Time frame: 1 year
Other
Cost of treatment and hospital stay (Relation between type of treatment and cost Of treatment, time of hospital stay) (type of treatment and number of days of hospital stay)
Time frame: 1 year
No study locations are listed for this record.
Plan to share: Undecided
This study is not yet recruiting, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.
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Assiut University