The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD)

Browse trials for

• Alzheimer Disease 3,678
• Dementia 2,172
• Cognitive Dysfunction 3,843

Alzheimer Disease

3,678 studies on the registry are indexed under Alzheimer Disease; 872 are open to participants now.

This study's planned enrollment of 209 is close to the median of 200 across 751 observational studies indexed under Alzheimer Disease.

Lead sponsor

The First Affiliated Hospital with Nanjing Medical University is the lead sponsor of 543 studies on the registry; 301 are open to participants now.

Study population

Groups and cohorts

• SI group (social isolation group)

  The LSNS-6 was used for assessing social networks among older Chinese. Lubben suggested using a score of less than 12 as a clinical cutoff point of the LSNS-6 to indicate social isolation, which meant, on average, the respondents had less than two people to perform social integration functions. 0≤LSNS-6≤12

  Behavioral: social isolation

• nonSI group (non-social isolation group)

  LSNS-6\>12

Interventions

• Behavioralsocial isolation

  social isolation (0≤LSNS-6≤12)

Primary outcomes

1. Incidence of Mild Cognitive Impairment (MCI)

   Incidence of Mild Cognitive Impairment (MCI)

   Time frame: through study completion, an average of 1 year

2. Incidence of Alzheimer's disease (AD)

   Incidence of Alzheimer's disease (AD)

   Time frame: through study completion, an average of 1 year

Secondary outcomes

1. AVLT-H

   Auditory Verbal Learning Test Huashan Version, AVLT-H The Auditory Verbal Learning Test-Huashan version (AVLT-H) assessment will be used as the primary outcome to assess EM for our study. The AVLT-H assesses several aspects of verbal EM through a list of 12 words, such as short or long-term delayed recall and recognition. It has been widely used as a semantic categorization memory test in mainland Chinese populations.

   Time frame: through study completion, an average of 1 year

2. MoCA

   Montreal Cognitive Assessment, MoCA Overall cognitive function will be assessed using scores from the Montreal Cognitive Assessment Test (MOCA).

   Time frame: through study completion, an average of 1 year

3. WMS-RLM

   Wechsler Memory Scale-Revised Logical Memory, WMS-RLM Participants were asked to recall the stories they had heard after listening to a short story containing 25 information points, with 1 point for each information point and 25 points for each story, for a total of two stories out of 50 points, with higher scores indicating better short-term memory.

   Time frame: through study completion, an average of 1 year

4. WDS

   Wechsler Digit Span, WDS The scale is divided into two parts, forward numerical memory and inverse numerical memory, with 12 items each, with a maximum of 12 points and a maximum score of 24 points, with higher scores leading to better short-term memory and attention.

   Time frame: through study completion, an average of 1 year

5. VFT

   Verbal Fluency Test, VFT This scale is a measure of verbal fluency and requires the test subject to say as many names as possible in one minute, with only one repeat counted and the total number recorded.

   Time frame: through study completion, an average of 1 year

6. BNT

   Boston Naming Test, BNT This scale, one of the most commonly used methods for diagnosing naming disorder, consists of 30 black-and-white pictures of objects commonly used in daily life, and the test subjects are asked to name the pictures and record the total number of correct responses.

   Time frame: through study completion, an average of 1 year

7. LSNS-6

   Lubben Social Network Scale-6, LSNS-6 The LSNS-6 could be a useful tool for assessing social networks among older mainland Chinese. In addition, suggestion is made to improve social networks, especially in family bonds and support, as a promising strategy in reducing late-life suicide risks in mainland China.

   Time frame: through study completion, an average of 1 year

8. UCLA

   UCLA Loneliness Scale, University of California at Los Angels The 20-item UCLA Loneliness Scale (Version 3; UCLA-3) is a commonly used assessment of loneliness, with strong test-retest reliability as well as high internal consistency and validity (Cronbach's α of .89 to .94).

   Time frame: through study completion, an average of 1 year

9. GDS

   Geriatric Depression Scale, GDS Participants completed the short form of the Geriatric Depression Scale (GDS), a 15-item assessment to screen for depression in older adults, with higher scores indicating greater severity.

   Time frame: through study completion, an average of 1 year

10. PSQI

    Pittsburgh sleep quality index, PSQI Self-reported sleep quality was assessed using the Pittsburgh Sleepiness Quality Index (PSQI).

    Time frame: through study completion, an average of 1 year

11. DTC

    Dual task consumption, DTC Dual-task cost (DTC) is the percentage change in walking speed between single-task and dual-task. It has been suggested that DTC predicts the risk of progression to dementia in older patients with MCI, with higher DTC and shorter time to progression to dementia and a higher risk.

    Time frame: through study completion, an average of 1 year

12. fMRI

    fMRI

    Time frame: Enrollment, 3, 5 years later

13. tau

    tau

    Time frame: Enrollment, 3, 5 years later

14. Aβ

    Aβ

    Time frame: Enrollment, 3, 5 years later

15. APOE genotyping

    APOE genotyping Genotypes for rs7412 and rs429358, the single nucleotide polymorphisms (SNPs) defining the ϵ-2, ϵ-3 and ϵ-4 alleles of APOE, were genotyped using the commercially available TaqMan® SNP Genotyping Assay (ThermoFisher Scientific).

    Time frame: Enrollment

16. TMT-A, TMT-B

    The online test is a connected test (Chinese revised version), and the test is divided into two parts, A and B, each of which includes exercises and tests. Before taking the test, the test taker should be asked to practice and then take the assessment. TMT-A requires the test subject to complete the connection from 1 to 25 as quickly as possible, in the order from smallest to largest, and the pen must not leave the paper during the connection. TMT-B requires the test subject to complete the connection from 1 to 25 as quickly as possible in the order of small to large, circle icon and square icon interval, and the pen must not leave the paper during the connection process. The time spent in each of the two parts is recorded.

    Time frame: through study completion, an average of 1 year