An interventional study of Mirogabalin and Pregabalin in Pain Postoperative, Osteoarthritis and Total Knee Arthroplasty, sponsored by Thammasat University Hospital. Recruiting at 1 site in Thailand. Open to participants aged 50 Years to 85 Years. Per ClinicalTrials.gov, last updated 2026-08-07.
Sponsored by Thammasat University Hospital · Not applicable, Interventional, and Treatment
The goal of this RCT is to compare efficacy between mirogabalin and pregabalin in pain reducing after unilateral primary total knee arthroplasty.
The main question[s] it aims to answer are:
Participants will randomized to mirogabalin or pregabalin group and will take the drug for 2 weeks after TKA. Researchers will compare to pregabalin group to see pain and functional outcomes after TKA.
After surgery is complete, you will be randomly assigned to receive painkillers Mirogabalin or Pregabalin along with other standard medications.
Surgery by Mirogabalin group: Participants received 5 mg of mirogabalin, one tablet taken twice a day, after breakfast and dinner, for 2 weeks.
In the pregabalin group: Participants received 75 mg of pregabalin, one tablet taken daily before bedtime, for 2 weeks.
5,093 studies on the registry are indexed under Pain, Postoperative; 1,140 are open to participants now.
This study's planned enrollment of 80 is close to the median of 75 across 4,344 interventional studies indexed under Pain, Postoperative.
Browse Pain, Postoperative studies →Thammasat University Hospital is the lead sponsor of 16 studies on the registry; 7 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants will receive 5 mg of mirogabalin, twice a day, after breakfast and dinner, for 2 weeks.
Drug: Mirogabalin
Participants will receive 75 mg of pregabalin, once a day before bedtime, for 2 weeks.
Drug: Pregabalin
Participants will receive 5 mg of mirogabalin, twice a day, after breakfast and dinner, for 2 weeks.
Participants will receive 75 mg of pregabalin, once a day before bedtime, for 2 weeks.
Pain score
Visual analog scale at rest and motion (0-100 points, 0 mean best, 100 mean worst)
Time frame: Every 6 hours after surgery for 2 days, then twice a day for 2 weeks, then once a week until 12 week after surgery.
Morphine consumption
Total morphine consumption in hospital (mg)
Time frame: 72 hours after surgery
Range of motion
Using long arm goniometer (degrees)
Time frame: 24 hour, 48 hour, 2 week, 6 week and 12 week after surgery
Knee society score
report in point (0-100, 0 mean worst, 100 mean best)
Time frame: 2 week, 6 week and 12 week after surgery
Knee injury and Osteoarthritis Outcome Score (KOOS)
report in point (0-100, 0 mean worst, 100 mean best)
Time frame: 2 week, 6 week and 12 week after surgery
Sedation score
report in point (0-100, 0 mean best, 100 mean worst)
Time frame: 24 hour, 48 hour, 2 week, 6 week and 12 week after surgery
Incidence of Somnolence and dizziness
Using scale "Mild, moderate and severe"
Time frame: everyday until 14 days then once a week until 12 weeks after surgery
Total hospital stay
Number of days the patient stays for surgery
Time frame: up to 1 week
Plan to share: No
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Thammasat University Hospital