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CompletedNCT06320548Updated Mar 20, 2024

The Efficacy of Preoperative Low-residue Diet on Postoperative Ileus Following Cesarean Section

An interventional study of Low-residue diet and Free diet in Cesarean Section Complications, sponsored by University of Roma La Sapienza. Completed at 1 site in Italy. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-03-20.

Sponsored by University of Roma La Sapienza · Not applicable, Interventional, and Supportive care

Phase
Not applicable
Study type
Interventional
Enrollment
166
Allocation
Randomized
Ages
18 Years and older
Sex
Female
01

Study summary

The aim of the present study was to evaluate the efficacy of preoperative low-residue diet on postoperative ileus in women undergoing elective cesarean section. It is a surgeon-blind, randomized controlled trial enrolling pregnant women at ≥39 weeks of gestation undergoing elective cesarean section. Patients were preoperatively randomized to receive either low-residue diet (arm A) or free diet (arm B) starting from three days before surgery. The primary outcome was the postoperative ileus at 24 hours after surgery. The secondary outcomes were the postoperative pain (assessed through VAS scale), the quality of the surgical field (scored using a 5-point scale, from poor to excellent), postoperative complications, and the length of hospital stay. Perioperative data were collected and compared between groups.

02

Conditions studied

  • Cesarean Section Complications

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Keywords

  • enhanced recovery after surgery
  • low-residue diet
  • obstetrics
  • perioperative management
  • cesarean section
  • postoperative ileus
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
Female
Accepts healthy volunteers
No

Inclusion criteria

  • Pregnant women at ≥39 weeks of gestation scheduled for elective cesarean section at the Department of Gynecology of Policlinico Umberto I (Sapienza University of Rome) who gave written informed consent.

Exclusion criteria

Exclusion Criteria:

  • Urgent/emergent surgery
  • Patients with gastrointestinal disorders
  • Complicated pregnancy (e.g., active infection, placental adhesive disorders, hypertensive disorders), which would potentially prolong their hospitalization
  • Incomplete medical records.
04

Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
166 participants (actual)

Study arms

  • Experimental
    Low-residue diet

    Patients received clear explanations, practical schemes, and a list of allowed foods, tailored to fit individual needs.

    Dietary Supplement: Low-residue diet

  • Active comparator
    Free diet

    Patients had free diet.

    Dietary Supplement: Free diet

Interventions

  • Dietary supplementLow-residue diet

    Patients received clear explanations, practical schemes, and a list of allowed foods, tailored to fit individual needs.

  • Dietary supplementFree diet

    Patients had free diet.

05

What researchers measure

Primary outcomes

  1. Number of participants who have passage of flatus within the first 24 hours after caesarean section.

    The primary outcome was postoperative ileus at 24 hours after caesarean section, the passage of flatus within the first 24 hours after caesarean section.

    Time frame: 24 hours after surgery

Secondary outcomes

  1. Postoperative pain

    Postoperative pain at 12, 24 and 48 hours postoperatively, assessed using the Visual Analogue Scale scale. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between "no pain" and "worst pain".

    Time frame: 12, 24, and 48 hours after surgery

  2. Postoperative complications

    Postoperative complications were classified according Clavien-Dindo classification system used to describe grade I-IV postoperative complications.

    Time frame: 24-48 hours after surgery

  3. Quality of the surgical field

    The degree of small and large bowel preparation and the overall appropriateness of the surgical field was assessed by the surgeon using a 5-point scale (poor, sufficient, medium, good, excellent), based on the Leiden-surgical rating scale.

    Time frame: Intraoperatively

06

Study locations

1 site
  • Sapienza University of Rome
    Rome, Italy
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT06320548
Lead sponsor
University of Roma La Sapienza
Responsible party
Giuseppe Caruso (Principal Investigator, University of Roma La Sapienza) — Principal investigator
First posted
Mar 20, 2024
Start date
Oct 1, 2018
Primary completion
Nov 30, 2020
Completion
Dec 2, 2020
Last update
Mar 20, 2024

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
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This study is completed, as verified in Mar 2024. You cannot join it, but the record below documents what was studied.

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