An interventional study of health education in Schistosomiasis and Health Education, sponsored by Pemba Ministry of Health Zanzibar. Completed at 1 site in Tanzania. Open to participants aged 7 Years to 15 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-08.
Sponsored by Pemba Ministry of Health Zanzibar · Not applicable, Interventional, and Health services research
The goal of this intervention study is to investigate the level of knowledge, attitudes, and behaviors of students on schistosomiasis in Pemba Island. It aims to test the effectiveness of establishing a widely applicable Community Health Volunteers model in the Zanzibar region and explore the feasibility of promoting this model in other areas of Africa. This study also aims to provide valuable insights and references for global schistosomiasis prevention and control efforts.
The main questions it aims to answer are:
Conducting a survey to understand the current knowledge levels, attitudes, and relevant health behaviors of Pemba Island students towards schistosomiasis.
Performing qualitative research to analyze the factors influencing students' knowledge, attitudes, and behaviors related to schistosomiasis, as well as observing the facilitators and barriers to conducting health education among student groups, in order to provide a scientific basis for targeted intervention measures.
Testing the effectiveness of establishing a widely applicable community health volunteer model in the Zanzibar region and exploring the feasibility of promoting this model in other regions of Africa, thereby providing insights and references for global schistosomiasis prevention and control efforts.
Participants will select fourth and fifth grade students from two schools located in high-risk schistosomiasis prevalence areas on Pemba Island, with Kilindi Primary School as the intervention group and Shumba Viamboni or Chambani primary school as the control group from Feb 2024 to Feb 2025. Apart from the KAP survey, urine samples will be collected from students three times at least and the prevalence confirmed to compare the effectiveness of the two groups.
79 studies on the registry are indexed under Schistosomiasis; 14 are open to participants now.
This study's enrollment of 978 is above the median of 289 across 52 interventional studies indexed under Schistosomiasis.
Browse Schistosomiasis studies →Pemba Ministry of Health Zanzibar is the lead sponsor of 2 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A group of students who receive schistosomiasis health education intervention led by community health volunteers.
Behavioral: health education
A group of students who do not receive schistosomiasis health education intervention led by community health volunteers. The control arm received conventional education.
A group of students who do not receive schistosomiasis health education intervention led by community health volunteers. The control arm received conventional education.
In the intervention group, we provide schistosomiasis health education to students once a month through community health volunteers for a duration of six months. After that, the community health volunteers no longer visit the school for health education until the completion of a one-year follow-up period.
Also known as: led by community health volunteers
Change in Infection Rate
For biological sample collection, students provided first-morning urine samples (30-50 mL) in sterile, pre-labeled wide-mouth containers under teacher supervision to ensure protocol adherence. Certified laboratory technicians performed standardized filtration and microscopic analysis to detect S. haematobium eggs. All egg counts were initially recorded manually, then entered into a Microsoft Excel database using dual-entry verification to maintain data integrity. Infection intensity classified by WHO criteria (light: 1-49 eggs/10ml urine; heavy: ≥ 50 eggs/10ml urine)
Time frame: before the intervention, six months after the intervention, and at the end of the one-year observation period
Change in Knowledge Scores
Measurement Tool: "Schistosomiasis Knowledge Questionnaire" Description: This questionnaire assesses the knowledge level of students regarding schistosomiasis. Scale Title: Schistosomiasis Knowledge Questionnaire Range: Minimum value: 0, Maximum value: 10 Interpretation: Higher scores indicate a better understanding of schistosomiasis
Time frame: before the intervention, six months after the intervention, and at the end of the one-year observation period
Attitudes Changes
Measurement Tool: "Schistosomiasis Attitudes Questionnaire" Description: This questionnaire assesses the attitudes level of students regarding schistosomiasis. Scale Title: Schistosomiasis Attitudes Questionnaire Range: Minimum value: 11, Maximum value: 55 Interpretation: Higher scores indicate more positive attitudes related to schistosomiasis
Time frame: before the intervention, six months after the intervention, and at the end of the one-year observation period
Behaviors Changes
Measurement Tool: "Schistosomiasis Behaviors Questionnaire" Description: This questionnaire assesses the behaviors level of students regarding schistosomiasis. Scale Title: Schistosomiasis Behaviors Questionnaire Range: Minimum value:10 , Maximum value:30 Interpretation: Higher scores indicate more positive behaviors related to schistosomiasis
Time frame: before the intervention, six months after the intervention, and at the end of the one-year observation period
| Milestone | CHVs Intervention Group | Control A | Control B |
|---|---|---|---|
| Started | 278 | 324 | 376 |
| Completed | 245 | 295 | 346 |
| Not completed | 33 | 29 | 30 |
For biological sample collection, students provided first-morning urine samples (30-50 mL) in sterile, pre-labeled wide-mouth containers under teacher supervision to ensure protocol adherence. Certified laboratory technicians performed standardized filtration and microscopic analysis to detect S. haematobium eggs. All egg counts were initially recorded manually, then entered into a Microsoft Excel database using dual-entry verification to maintain data integrity. Infection intensity classified by WHO criteria (light: 1-49 eggs/10ml urine; heavy: ≥ 50 eggs/10ml urine)
| Number of Participants with S. haematobi | CHVs Intervention Group | Control A | Control B |
|---|---|---|---|
| baseline(T1) | 47 | 35 | 3 |
| six months after the intervention（T2） | 6 | 4 | 3 |
| at the end of the one-year observation period（T3） | 2 | 3 | 5 |
Measurement Tool: "Schistosomiasis Knowledge Questionnaire" Description: This questionnaire assesses the knowledge level of students regarding schistosomiasis. Scale Title: Schistosomiasis Knowledge Questionnaire Range: Minimum value: 0, Maximum value: 10 Interpretation: Higher scores indicate a better understanding of schistosomiasis
| Scores | CHVs Intervention Group | Control A | Control B |
|---|---|---|---|
| baseline（T1） | 6.11 ± 1.79 | 6.42 ± 1.56 | 6.27 ± 1.47 |
| six months after the intervention（T2） | 7.13 ± 1.44 | 6.62 ± 1.32 | 7.22 ± 1.23 |
| at the end of the one-year observation period（T3） | 7.11 ± 1.35 | 6.56 ± 1.70 | 6.62 ± 1.56 |
Measurement Tool: "Schistosomiasis Attitudes Questionnaire" Description: This questionnaire assesses the attitudes level of students regarding schistosomiasis. Scale Title: Schistosomiasis Attitudes Questionnaire Range: Minimum value: 11, Maximum value: 55 Interpretation: Higher scores indicate more positive attitudes related to schistosomiasis
| Scores | CHVs Intervention Group | Control A | Control B |
|---|---|---|---|
| baseline（T1） | 38.02 ± 8.49 | 39.06 ± 8.96 | 39.37 ± 9.98 |
| six months after the intervention（T2） | 41.2 ± 8.66 | 41.24 ± 8.15 | 42.55 ± 8.85 |
| at the end of the one-year observation period（T3） | 43.58 ± 8.95 | 41.39 ± 8.58 | 41.44 ± 10.68 |
Measurement Tool: "Schistosomiasis Behaviors Questionnaire" Description: This questionnaire assesses the behaviors level of students regarding schistosomiasis. Scale Title: Schistosomiasis Behaviors Questionnaire Range: Minimum value:10 , Maximum value:30 Interpretation: Higher scores indicate more positive behaviors related to schistosomiasis
| Scores | CHVs Intervention Group | Control A | Control B |
|---|---|---|---|
| baseline（T1） | 19.05 ± 2.74 | 19.35 ± 2.87 | 19.43 ± 2.62 |
| six months after the intervention（T2） | 20.56 ± 2.84 | 20.25 ± 2.64 | 19.77 ± 2.59 |
| at the end of the one-year observation period（T3） | 20.7 ± 2.912 | 20.14 ± 2.66 | 19.6 ± 2.6 |
Collected over During the two subsequent follow-up waves : six months after the intervention(2024.08.30): strict individual self-matching and accounting for attrition (school transfers, absenteeism, and incomplete samples; at the end of the one-year observation period(2025.02.27): strict individual self-matching and accounting for attrition (school transfers, absenteeism, and incomplete samples. Non-serious events are listed at a 0% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| CHVs Intervention Group | 0/278 (0%) | 0/278 (0%) | 33/278 (11.9%) |
| Control A | 0/324 (0%) | 0/324 (0%) | 29/324 (9%) |
| Control B | 0/376 (0%) | 0/376 (0%) | 30/376 (8%) |
| Event | CHVs Intervention Group | Control A | Control B |
|---|---|---|---|
| incomplete samplesInvestigations | 25/278 | 23/324 | 20/376 |
| absenteeismInvestigations | 5/278 | 4/324 | 6/376 |
| school transfersInvestigations | 3/278 | 2/324 | 4/376 |
| Age, Continuous(years) | CHVs Intervention Group | Control A | Control B | Total |
|---|---|---|---|---|
| Mean | 11.75 ± 1.441 | 11.98 ± 1.370 | 11.97 ± 1.368 | 11.87 ± 1.405 |
| Sex: Female, Male(Participants) | CHVs Intervention Group | Control A | Control B | Total |
|---|---|---|---|---|
| Female | 145 | 182 | 208 | 535 |
| Male | 100 | 113 | 138 | 351 |
| Ethnicity (NIH/OMB)(Participants) | CHVs Intervention Group | Control A | Control B | Total |
|---|---|---|---|---|
| Hispanic or Latino | 0 | 0 | 0 | 0 |
| Not Hispanic or Latino | 0 | 0 | 0 | 0 |
| Unknown or Not Reported | 245 | 295 | 346 | 886 |
PDFs hosted by the registry, ClinicalTrials.gov.
Ran from Feb 2024 to primary completion in Feb 2025, 12 months.
Results were first posted in Oct 2025, 7 months after primary completion.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Pemba Ministry of Health Zanzibar