An interventional study of Sodium nitrate in Hypertension, sponsored by University of Sao Paulo. Completed at 1 site in Brazil. Open to female participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-03-12.
Sponsored by University of Sao Paulo · Not applicable, Interventional, and Treatment
Inorganic nitrite and nitrate can be reduced to NO and NO-related species such as S-nitrosothiols via the nitrate-nitrite-NO pathway. This is due to the reduction of nitrate to nitrite by the action of bacteria in the mouth and the reduction of nitrite to NO depending on the acidic pH on the stomach or by enzymes with nitrite-reductase activity. The acidic environment of the stomach is very important to the formation of NO and S-nitrosothiols and several studies suggest that changes in gastric pH can affect this conversion. In this context, bariatric surgery, by altering the anatomy of the stomach and increasing gastric pH, can affect the nitrate-nitrite-NO pathway and change the antihypertensive and antioxidant effect of sodium nitrate.
6,690 studies on the registry are indexed under Hypertension; 966 are open to participants now.
This study's enrollment of 30 is below the median of 90 across 4,996 interventional studies indexed under Hypertension.
Browse Hypertension studies →University of Sao Paulo is the lead sponsor of 1,005 studies on the registry; 90 are open to participants now.
Of its 7 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
For volunteers who underwent bariatric surgery:
For voluntary controls:
Exclusion Criteria:
For volunteers who underwent bariatric surgery and controls:
Sodium nitrate, once a day for 14 days
Dietary Supplement: Sodium nitrate
Sodium nitrate, once a day for 14 days
Dietary Supplement: Sodium nitrate
Sodium Nitrate
Assess changes in s-nitrosothiols
Change in s-nitrosothiols concentration in plasma After Sodium Nitrate Treatment
Time frame: 14 days
Assess changes in blood pressure
Change in Blood Pressure After Sodium Nitrate Treatment by Ambulatory blood pressure monitors (ABPMs)
Time frame: 14 days
Assess changes in endotelial function
Change in endotelial function After Sodium Nitrate Treatment by Endopat
Time frame: 14 days
Assess changes in Vascular stiffness
Change in Vascular stiffness After Sodium Nitrate Treatment by pulse wave velocity (PWV)
Time frame: 14 days
Assess changes in nitrate concentration
Change in nitrate concentration in plasma After Sodium Nitrate Treatment
Time frame: 14 days
Assess changes in nitrite concentration
Change in nitrite concentration in plasma After Sodium Nitrate Treatment
Time frame: 14 days
Plan to share: No
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This study is completed, as verified in Mar 2024. You cannot join it, but the record below documents what was studied.
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University of Sao Paulo