An interventional study of : Implementation strategy to improve hypertension care in geopolitically defined communities in Preventive Medicine and Hypertension, sponsored by Yale University. Not yet recruiting at 1 site in United States. Open to participants aged 40 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-08.
Sponsored by Yale University · Not applicable, Interventional, and Other
Brain disease and heart disease are the leading causes of death and disability in the US; at least 60% of cases can be attributed to modifiable risk factors such as hypertension, dyslipidemia, and poor-quality diet. Our mission is to deliver high-quality preventive care to whole geopolitically defined communities, reaching every resident. ThumpThump is a novel implementation strategy that 1) uses sociology, marketing, and behavioral science to engage residents and 2) adapts population health methods from high-functioning health systems to geopolitically defined communities. ThumpThump is starting with hypertension in Derby, CT in collaboration with city residents and city leaders.
The ThumpThump Pilot Study will estimate the likelihood that a large, definitive trial of ThumpThump can succeed. The pilot study will enroll 150 residents who are at least 40 years of age. Specific aims are: 1) demonstrate ThumpThump can reach residents of Derby, 2) measure and achieve fidelity to standard hypertension care, and 3) measure success in applying our implementation strategy. The pilot is a one-arm trial.
Proven population health methods from high-functioning health systems will be used to first classify participants according to hypertension (none, controlled, uncontrolled) and then help those in need get to goal. Home blood pressure cuffs will be given to all participants. Participants with no or controlled hypertension will have blood pressure re-measured at three and six months. Participants with uncontrolled hypertension will be offered two options: 1) to continue care from their personal healthcare professional or 2) to receive hypertension care directly from our team. With either method, the study will continue to monitor their blood pressure regularly. If they continue to receive care from their personal professional, participants will be offered support in following that professional's plan and the study will communicate and coordinate with their professional as appropriate. If they chose our team, a treatment algorithm will be used to help them get to their BP goal. Community health workers will be employed for participant enrollment and follow-up care (e.g., health education, blood pressure monitoring, treatment implementation, and navigation within health systems). Team care will include working with local health care professionals and institutions to advance a mutual mission, not replace their function. If successful, funds for a definitive trial will be sought with the long-term goal of targeting more risk factors and expanding to more communities.
6,689 studies on the registry are indexed under Hypertension; 965 are open to participants now.
This study's planned enrollment of 3,680 is above the median of 90 across 4,995 interventional studies indexed under Hypertension.
Browse Hypertension studies →Yale University is the lead sponsor of 1,725 studies on the registry; 299 are open to participants now.
Of its 210 completed or terminated interventional studies of FDA-regulated products, 126 (60%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Implementation strategy to improve hypertension care in geopolitically defined communities
Other: : Implementation strategy to improve hypertension care in geopolitically defined communities
The implementation strategy has two stages. The first stage uses methods to reach adult residents of Derby for blood pressure measurement and enrollment in the PROSPER Clinical Trial for hypertension care (i.e., marketing to change how residents regard hypertension and cardiovascular health, social contagion techniques based on social network science to draw residents to PROSPER and develop interest in cardiovascular health, and financial incentives). The second stage adapts implementation methods developed for high performing practices and health systems to improve delivery of evidence-based hypertension care in a different context, which is the community (e.g., task-shifting and team care, standardized and client centered care, and audit and feedback with rapid small cycles of change).
Engagement of adult residents of Derby (reach)
Enrollment of 150 residents of the city of Derby
Time frame: 3 months from start of study
Fidelity to evidence-based hypertension classification
Proportion of enrolled subjects who complete hypertension classification
Time frame: 3 months from start of study
Fidelity to evidence-based hypertension treatment
Proportion of enrolled subjects with uncontrolled hypertension who receive guideline-directed hypertension treatment within 2 months of treatment initiation
Time frame: 2 months from initiation of hypertension therapy
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Yale University