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RecruitingNCT06275061COMESUpdated Feb 23, 2024

Chinese Obesity and MEtabolic Surgery Database (COMES Database)

An observational study in Obesity, Metabolic Surgery and Bariatric Surgery, sponsored by Jinan University Guangzhou. Recruiting at 1 site in China. Per ClinicalTrials.gov, last updated 2024-02-23.

Sponsored by Jinan University Guangzhou · Observational

From the registry’s dates

  • Started May 2020; still recruiting 6 years 5 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
1,000,000
Sex
All
01

Study summary

The purpose of the Chinese Obesity and MEtabolic Surgery Database (COMES Database) is to collect data and examine the long-term effects of metabolic and bariatric surgery on obesity and metabolic disorders in the Chinese population.

Read the detailed description

COMES Database is a prospective managed national database to collect data and examine the long-term effects of metabolic and bariatric surgery on obesity and metabolic disorders in the Chinese population.

02

Conditions studied

  • Obesity
  • Metabolic Surgery
  • Bariatric Surgery
  • Weight Loss

Keywords

  • Obesity
  • Metabolic Surgery
  • Bariatric Surgery
  • Weight Loss
03

In context

Obesity

6,296 studies on the registry are indexed under Obesity; 1,692 are open to participants now.

This study's planned enrollment of 1,000,000 is above the median of 135 across 1,283 observational studies indexed under Obesity.

Browse Obesity studies →

Lead sponsor

Jinan University Guangzhou is the lead sponsor of 12 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Patients diagnosed as obesity undergoing metabolic and bariatric surgery.

Inclusion criteria

  • Patients diagnosed as obesity undergoing metabolic and bariatric surgery.

Exclusion criteria

Exclusion Criteria:

  • Patients treated by non-surgical modalities.
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
1,000,000 participants (estimated)
Target follow-up
30 Years
Patient registry
Yes

Groups and cohorts

  • Metabolic and Bariatric Surgery

    Metabolic and bariatric surgery is weight loss surgery that results in weight loss and resolution of metabolic disorders.

    Procedure: Metabolic and Bariatric Surgery

Interventions

  • ProcedureMetabolic and Bariatric Surgery

    Metabolic and bariatric surgery is weight loss surgery that results in weight loss and resolution of metabolic disorders.

06

What researchers measure

Primary outcomes

  1. Excess weight loss effect of metabolic and bariatric surgery after 1 year

    Percent excess weight loss (%EWL) = \[(initial weight)-(post-op weight)\]/\[(initial weight)-(ideal weight)\]

    Time frame: 1 year

Secondary outcomes

  1. Excess weight loss effect of metabolic and bariatric surgery in long-term follow-ups

    Percent excess weight loss (%EWL) = \[(initial weight)-(post-op weight)\]/\[(initial weight)-(ideal weight)\]

    Time frame: 3 years

  2. Excess weight loss effect of metabolic and bariatric surgery in long-term follow-ups

    Percent excess weight loss (%EWL) = \[(initial weight)-(post-op weight)\]/\[(initial weight)-(ideal weight)\]

    Time frame: 5 years

  3. Excess weight loss effect of metabolic and bariatric surgery in long-term follow-ups

    Percent excess weight loss (%EWL) = \[(initial weight)-(post-op weight)\]/\[(initial weight)-(ideal weight)\]

    Time frame: 10 years

  4. Glycemic control effect of metabolic and bariatric surgery after 1 year

    Change of HbA1c levels

    Time frame: 1 year

  5. Glycemic control effect of metabolic and bariatric surgery in long-term follow-ups

    Change of HbA1c levels

    Time frame: 3 years

  6. Glycemic control effect of metabolic and bariatric surgery in long-term follow-ups

    Change of HbA1c levels

    Time frame: 5 years

  7. Glycemic control effect of metabolic and bariatric surgery in long-term follow-ups

    Change of HbA1c levels

    Time frame: 10 years

  8. Glycemic control effect of metabolic and bariatric surgery after 1 year

    Change of blood glucose levels

    Time frame: 1 year

  9. Glycemic control effect of metabolic and bariatric surgery in long-term follow-ups

    Change of blood glucose levels

    Time frame: 3 years

  10. Glycemic control effect of metabolic and bariatric surgery in long-term follow-ups

    Change of blood glucose levels

    Time frame: 5 years

  11. Glycemic control effect of metabolic and bariatric surgery in long-term follow-ups

    Change of blood glucose levels

    Time frame: 10 years

  12. Glycemic control effect of metabolic and bariatric surgery after 1 year

    Change of C-peptide levels

    Time frame: 1 year

  13. Glycemic control effect of metabolic and bariatric surgery in long-term follow-ups

    Change of C-peptide levels

    Time frame: 3 years

  14. Glycemic control effect of metabolic and bariatric surgery in long-term follow-ups

    Change of C-peptide levels

    Time frame: 5 years

  15. Glycemic control effect of metabolic and bariatric surgery in long-term follow-ups

    Change of C-peptide levels

    Time frame: 10 years

  16. Glycemic control effect of metabolic and bariatric surgery after 1 year

    Change of insulin levels

    Time frame: 1 year

  17. Glycemic control effect of metabolic and bariatric surgery in long-term follow-ups

    Change of insulin levels

    Time frame: 3 years

  18. Glycemic control effect of metabolic and bariatric surgery in long-term follow-ups

    Change of insulin levels

    Time frame: 5 years

  19. Glycemic control effect of metabolic and bariatric surgery in long-term follow-ups

    Change of insulin levels

    Time frame: 10 years

Other outcomes

  1. Adverse events rate of metabolic and bariatric surgery

    Surgical safety by 30 days follow-up according to guideline

    Time frame: 30 days after surgery

07

Study locations

1 of 1 sites recruiting
  • The First Affiliated Hospital of Jinan University
    Guangzhou, Guangdong 510630, China
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 23, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06275061
Lead sponsor
Jinan University Guangzhou
Collaborators
Chinese Obesity and Metabolic Surgery Collaborative
Responsible party
Wah Yang, MD (Principal Investigator, Jinan University Guangzhou) — Principal investigator
First posted
Feb 23, 2024
Start date
May 1, 2020
Primary completion
Dec 31, 2030 (estimated)
Completion
Dec 31, 2040 (estimated)
Last update
Feb 23, 2024

Study contacts

Wah Yang, MD
Contact
yangwah@qq.com
+8615920373823
Cunchuan Wang, MD, PhD
study chair · First Affiliated Hospital of Jinan University
Wah Yang, MD
study director · First Affiliated Hospital of Jinan University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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