An observational study in Thyroid Cancer and Thyroid Cancer, Papillary, sponsored by Fujian Medical University. Recruiting at 1 site in China. Per ClinicalTrials.gov, last updated 2025-05-20.
Sponsored by Fujian Medical University · Observational
Among 40 studies in Thyroid Cancer, Papillary with a site in China — 24 open to participants now, 26 under way, 1 of them phase 3. Thyroid Cancer, Papillary · China.
Among the 40 studies in Thyroid Cancer, Papillary with a site in China, this one is the 18th largest by planned enrollment of the 19 observational ones that give a count, is one of 10 that started in 2024, is one of 19 observational ones, reaches primary completion later than 9 of the 25 other live ones, and was the 21st registered.
186 studies on the registry are indexed under Thyroid Cancer, Papillary; 51 are open to participants now.
Browse Thyroid Cancer, Papillary studies →24 of the 40 studies in Thyroid Cancer, Papillary with a site in China are open now. Recruiting first, the newest first:
Ming-an Yu · Sites in China
Ages 16–60
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Sites in China
Second Affiliated Hospital of Xi'an Jiaotong University · Sites in China
Ages 16–80
Shanghai 6th People's Hospital · Sites in China
Chinese PLA General Hospital · Sites in China
Ages 18+
A study can be open while its sites in China have not opened yet or have stopped. Only those recruiting at a site in China →
Of the 33 Thyroid Cancer, Papillary studies recruiting now, 20 (61%) set no upper age limit and 8 (24%) stop at 75 or younger; 15 take children under 18; 3 take healthy volunteers.
This study: all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
40 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 3 · Phase 2 3 · Phase 3 1 · Phase 4 2
First in 2015; this study’s year is marked. 10 started in 2024.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 100 is below the median of 200 across 66 observational studies indexed under Thyroid Cancer, Papillary.
Median enrollment 170 across the 21 interventional studies, 541 across the 19 observational. Of the 10 that completed or were terminated, 2 (20%) have results posted.
This tab as a report to print or save as PDF → With an account.
3 of 40 have an industry lead sponsor. The 10 most frequent:
Fujian Medical University is the lead sponsor of 148 studies on the registry; 52 are open to participants now.
Fujian Medical University has 4 studies filed under Thyroid Cancer, Papillary — fewer than ten, so there is no comparison to draw.
6 of the studies in Thyroid Cancer, Papillary with a site in China that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07357571Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityPreoperative Prediction of Lymph Node Metastasis in T1N0M0 Papillary Thyroid Carcinoma by Using Contrast-enhanced Ultrasound | 2026-12-31 |
| NCT06316895Chinese PLA General HospitalThe Clinical Outcomes and Prediction of Thermal Ablation for Low-risk Papillary Thyroid Carcinoma | 2027-04-01 |
| NCT06804863West China HospitalRegret Emotion After Thyroidectomy in Low-Risk Papillary Thyroid Cancer | 2027-05-01 |
| NCT06610604Ming-an YuHealth-Related Quality of Life and Emotions in Patients with Thyroid Nodules | 2027-06 |
| NCT02650401Hoffmann-La RocheStudy Of Entrectinib (Rxdx-101) in Children and Adolescents With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options | 2027-06-30 |
Among the 40 studies in Thyroid Cancer, Papillary with a site in China, from their registry updates:
Nothing recorded among them since 2026-09-25.
This tab as a report to print or save as PDF → With an account.
This study examines the impact of intraoperative recurrent laryngeal nerve monitoring signal changes on the postoperative voice quality of thyroid surgery patients. By analyzing extensive surgical data and postoperative voice recordings, the investigation seeks to identify patterns in the variations of these signals and their correlation with voice quality outcomes. The goal is to enhance clinical understanding and surgical practices, allowing for more precise assessments of nerve function, informed surgical interventions, and improved postoperative patient well-being.
This research project conducts a detailed exploration into the fluctuations of intraoperative recurrent laryngeal nerve monitoring signals during thyroid surgery and their subsequent effects on the voice quality of patients after surgery. The study meticulously analyzes a comprehensive dataset comprised of surgical records and voice analyses conducted before and after the procedure. The primary objective is to pinpoint specific trends and changes in the nerve monitoring signals and to determine how these alterations correlate with the postoperative acoustic characteristics of patients' voices. By establishing a clear link between intraoperative signal dynamics and postoperative voice outcomes, the investigation aims to advance the field of thyroid surgery. This includes providing surgeons with critical insights for the precise evaluation of recurrent laryngeal nerve functionality, enabling targeted interventions during operations, and ultimately contributing to the enhancement of patients' quality of life following surgery. Through this rigorous analysis, the study seeks to contribute valuable knowledge to the surgical community, facilitating improved patient care and outcomes in thyroid surgery.
186 studies on the registry are indexed under Thyroid Cancer, Papillary; 51 are open to participants now.
This study's planned enrollment of 100 is below the median of 200 across 66 observational studies indexed under Thyroid Cancer, Papillary.
Browse Thyroid Cancer, Papillary studies →Fujian Medical University is the lead sponsor of 148 studies on the registry; 52 are open to participants now.
Compared within Thyroid Cancer, Papillary, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Thyroid Neoplasms. The counts are of registry records indexed under each term, refreshed daily. How we classify →
People with thyroid cancer who are planned to undergo traditional surgical treatment.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
During the surgical procedure, there was no occurrence of a decrease in recurrent laryngeal nerve signals or a decrease of less than 10%.
Procedure: Traditional thyroid surgery.
During the surgical procedure, the signal of the recurrent laryngeal nerve decreased by 10-50%.
Procedure: Traditional thyroid surgery.
During the surgical procedure, the signal of the recurrent laryngeal nerve decreased by 50-90%.
Procedure: Traditional thyroid surgery.
During the surgical procedure, the signal of the recurrent laryngeal nerve decreased by more than 90% or completely disappeared.
Procedure: Traditional thyroid surgery.
The patient undergoes traditional thyroid surgery with concurrent intraoperative nerve monitoring technology.
Intraoperative electromyographic signals.
Recording intraoperative electromyographic signals, including vagus nerve V1 and V2 signals, recurrent laryngeal nerve R1 and R2 signals.
Time frame: During the surgery, record R1 and V1 signals when initially identifying the recurrent laryngeal nerve or vagus nerve. After the surgery, record R2 and V2 signals upon re-identification of the recurrent laryngeal nerve or vagus nerve.
Voice analysis data(SPL)
Recording data(SPL) of voice tests before and after the surgery, sound pressure level in dB(A)
Time frame: Before the surgery, 2 weeks after the surgery, 2 months after the surgery, 4 months after the surgery, and 6 months after the surgery.
Voice analysis data(F0)
Recording data(F0) of voice tests before and after the surgery, F0 in Hz
Time frame: Before the surgery, 2 weeks after the surgery, 2 months after the surgery, 4 months after the surgery, and 6 months after the surgery.
Voice analysis data(Jitter)
Recording data(Jitter) of voice tests before and after the surgery, Jitter in percentage
Time frame: Before the surgery, 2 weeks after the surgery, 2 months after the surgery, 4 months after the surgery, and 6 months after the surgery.
Voice analysis data(Shimmer)
Recording data(Shimmer) of voice tests before and after the surgery, Shimmer in percentage
Time frame: Before the surgery, 2 weeks after the surgery, 2 months after the surgery, 4 months after the surgery, and 6 months after the surgery.
RBH
Conducted by an otolaryngologist, the RBH assessment includes R (Roughness), B (Breathiness), and H (Hoarseness).
Time frame: Before the surgery, 2 weeks after the surgery, 2 months after the surgery, 4 months after the surgery, and 6 months after the surgery.
VHI-30
Voice Handicap Index, including a scale with 30 items.The full, non-abbreviated title of the VHI-30 scale is the "Voice Handicap Index-30," and it is translated as the "Voice Disorder Severity Index." The scale ranges from a minimum score of 0 to a maximum of 120, with higher scores indicating poorer outcomes.
Time frame: Before the surgery, 2 weeks after the surgery, 2 months after the surgery, 4 months after the surgery, and 6 months after the surgery.
Neural Width
Recorded width of the recurrent laryngeal nerve in millimeters.
Time frame: During surgery.
Is there branching
Note if the recurrent laryngeal nerve branches.
Time frame: During surgery.
Number of neural branches
If there are branches in the recurrent laryngeal nerve, record the number of branches.
Time frame: During surgery.
Plan to share: No
No publications or documents are linked to this record.
Started Mar 2024 (actual). Primary completion is estimated for Dec 2025, 21 months after the start.
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