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CompletedNCT06250855Updated Dec 23, 2025

Observational Prospective Clinical Investigation on Monofocal Toric Intraocular Lens

An observational study in Cataract and Astigmatism, sponsored by SIFI SpA. Completed at 2 sites in Romania. Open to participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2025-12-23.

Sponsored by SIFI SpA · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
105
Ages
18 Years to 100 Years
Sex
All
01

Study summary

Evaluation, at least one-year long-term, of the clinical performance and safety of Mini Toric Ready Intraocular Lens (IOL), a monofocal toric intraocular lens.

Read the detailed description

Observational prospective clinical investigation based on the medical records of patients who undergone uncomplicated cataract surgery with implantation of Mini Toric Ready IOL and on a clinical visit after at least one year from the surgery. Eyes with corneal astigmatism ≥0.75 diopters were included. Postoperative evaluations included monocular or binocular uncorrected and corrected distance visual acuity; contrast sensitivity measured after at least one-year postoperatively.

02

Conditions studied

  • Cataract
  • Astigmatism

Keywords

  • Cataract
  • Astigmatism
  • Monofocal IOL
  • Toric IOL
03

Who can participate

Ages eligible
18 Years to 100 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Adults (males and females) ≥18 years with cataract and pre-existing corneal astigmatism who have undergone monocular or binocular Mini Toric Ready implantation. Subjects enrolled in the investigation underwent cataract surgery in which the cataract lens was removed by phacoemulsification, with circular capsulorhexis, leaving the posterior capsule intact.

Inclusion criteria

  • Eighteen years of age or older at the time of surgery and diagnosed with unilateral or bilateral cataracts;
  • Preoperative total corneal astigmatism ≥0.75D;
  • Unilateral or bilateral cataract removal by phacoemulsification;
  • Clear intraocular media other than cataract;
  • Willing and able to complete all required postoperative visits;
  • Able to comprehend and sign a statement of informed consent consistent with local regulation for research in human subjects.

Exclusion criteria

Exclusion Criteria:

  • Subjects participating in a concurrent clinical trial or if they have participated in an ophthalmology clinical trial within the last 30 days before the surgery.
04

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
105 participants (actual)
Patient registry
No

Interventions

  • DeviceMini Toric IOL

    Adults (males and females) ≥18 years with cataract and pre-existing corneal astigmatism who have undergone monocular or binocular Mini Toric Ready implantation after cataract surgery in which the cataract lens was removed by phacoemulsification, with circular capsulorhexis, leaving the posterior capsule intact.

05

What researchers measure

Primary outcomes

  1. Evaluation of the Visual Performance

    Evaluate Mini Toric Ready Intraocular Lens (IOL) performance in terms of correction of spherical and cylindrical visual defects, corrected and uncorrected monocular and/or binocular distance visual acuity at least 12 months post implant.

    Time frame: From 12 to 24 months post-surgery

Secondary outcomes

  1. Evaluation of the Stability

    Intraocular Lens (IOL) Rotation Stability

    Time frame: From 12 to 24 months post-surgery

Other outcomes

  1. Evaluation of the safety profile: Adverse Events (AEs)

    Incidence of Adverse events such as Posterior Capsular Opacification (PCO)

    Time frame: From 12 to 24 months post-surgery

  2. Evaluation of the safety profile

    Rate of secondary surgical interventions (SSIs) related to the optical properties of the IOL after at least 12 months post implant.

    Time frame: From 12 to 24 months post-surgery

06

Study locations

2 sites
  • Gauss Clinic Bacau
    Bacau, 600269, Romania
  • Immunoeye SRL
    Sfantu Gheorghe, 520024, Romania
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT06250855
Lead sponsor
SIFI SpA
Responsible party
Sponsor
First posted
Feb 9, 2024
Start date
Apr 24, 2024
Primary completion
Oct 27, 2024
Completion
Oct 27, 2024
Last update
Dec 23, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.

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