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CompletedNCT06245798Updated Feb 7, 2024

Liver Resection for Patients With Hepatocellular Carcinoma and Clinically Significant Portal Hypertension

An observational study in Hepatic Carcinoma, sponsored by Tang-Du Hospital. Completed at 2 sites in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-02-07.

Sponsored by Tang-Du Hospital · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
3,000
Ages
18 Years and older
Sex
All
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Study summary

Clinically significant portal hypertension limits the therapeutic options for hepatocellular carcinoma (HCC), which is closely associated with patient prognosis. HCC patients with CPSH are heterogeneous and treatment allocation remains controversial. The aim of this study was to compare the survival benefits of liver resection (LR) and transarterial chemoembolisation (TACE) in these populations.

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Conditions studied

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In context

Carcinoma

6,738 studies on the registry are indexed under Carcinoma; 1,159 are open to participants now.

This study's enrollment of 3,000 is above the median of 149 across 1,175 observational studies indexed under Carcinoma.

Browse Carcinoma studies →

Lead sponsor

Tang-Du Hospital is the lead sponsor of 164 studies on the registry; 77 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Sampling method
Probability sample

Study population

Study data were extracted from a nationwide database of HCC patients treated at 15 Chinese centres between January 2012 and December 2022. We included patients who were diagnosed with HCC according to the American Association for the Study of the Liver Disease/European Association for the Study of the Liver Guidelines and who received conventional liver resection or transarterial chemoembolisation

Inclusion criteria

  • HCC patients treated conventional liver resection or transarterial chemoembolisation

Exclusion criteria

Exclusion Criteria:

  • (1) presence of types III/IV portal vein tumour thrombosis (PVTT), hepatic artery, biliary duct or inferior vena cava invasion; (2) presence of extrahepatic spread (EHS); (3) underwent previous treatments; (4) Eastern Cooperative Oncology Group Performance Status (ECOG-PS) >1; (5) diffuse tumor nodules; (6) combined with other tumours or severe cardiac, cerebral, and renal insufficiency; (7) non-Clinically significant portal hypertension(CSPH), and (8) absence of baseline information
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
3,000 participants (actual)
Patient registry
No

Groups and cohorts

  • liver resection
  • transarterial chemoembolisation

    Procedure: transarterial chemoembolisation

Interventions

  • Proceduretransarterial chemoembolisation

    During transarterial chemoembolisation(TACE), a vascular catheter was selectively inserted into the tumour-feeding artery with an injection containing a mixture of doxorubicin (10-50 mg) and lipiodol (2-20 mL), followed by embolisation using gelatin sponge particles. TACE was repeated when residual viable tumours were confirmed or new lesions developed in patients with adequate liver function

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What researchers measure

Primary outcomes

  1. overall survival rate

    overall survival rate

    Time frame: 5 year

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Study locations

2 sites
  • Tangdu hospital
    Xian, Shaanxi 710000, China
  • Xijing hospital
    Xian, Shaanxi 710000, China
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 7, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06245798
Lead sponsor
Tang-Du Hospital
Responsible party
Sponsor
First posted
Feb 7, 2024
Start date
Jan 1, 2023
Primary completion
Apr 1, 2023
Completion
Dec 1, 2023
Last update
Feb 7, 2024

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2024. You cannot join it, but the record below documents what was studied.

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