An interventional study of Multi-Field-Strength Brain MRI in Healthy Adult Brain Imaging, sponsored by Tang-Du Hospital. Recruiting at 1 site in China. Open to participants aged 16 Years to 66 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-25.
Sponsored by Tang-Du Hospital · Not applicable, Interventional, and Basic science
This prospective imaging study aims to construct a multi-field-strength magnetic resonance imaging (MRI) brain atlas for healthy Chinese adults. Healthy volunteers will undergo standardized brain MRI examinations at multiple magnetic field strengths, including 0.55T, 1.5T, 3T, 5T, and 7T. Structural, diffusion, functional, and other quantitative MRI data will be acquired and analyzed. The study will characterize the consistency and differences in brain morphology and imaging measurements across field strengths and establish standardized multi-field-strength brain templates and reference data for healthy Chinese adults.
This is a prospective multi-field-strength neuroimaging study involving healthy Chinese adults. Eligible participants will undergo standardized brain MRI examinations at 0.55T, 1.5T, 3T, 5T, and 7T according to the study protocol.
MRI acquisitions include structural imaging, diffusion imaging, functional imaging, and quantitative imaging sequences where applicable. Images will undergo standardized preprocessing, registration, segmentation, and quantitative analysis. Multi-field-strength brain templates will be constructed, and anatomical and functional imaging characteristics will be compared across magnetic field strengths.
The study aims to establish normative multi-field-strength MRI reference data and brain atlases for healthy Chinese adults and to evaluate the consistency and field-strength-related differences in brain morphometry, cortical measurements, diffusion characteristics, functional connectivity, and other quantitative MRI parameters.
Female participants must not be pregnant. No current or previous clinical diagnosis of severe neurological or psychiatric disorders, such as schizophrenia, dementia, epilepsy, or severe sequelae of traumatic brain injury.
No obvious intracranial lesions or structural abnormalities identified on routine MRI examination.
Exclusion Criteria:
Severe claustrophobia preventing completion of the MRI examination. Pregnancy. Current or previous clinical diagnosis of severe neurological or psychiatric disorders.
History of severe head trauma, brain tumor, stroke, brain surgery, or other conditions that may substantially affect brain structure or function.
MRI data of insufficient quality for analysis due to marked discomfort, excessive head motion, or other causes during the examination.
Healthy Chinese adult volunteers will undergo standardized brain MRI examinations at multiple magnetic field strengths according to the study protocol.
Diagnostic Test: Multi-Field-Strength Brain MRI
Participants will undergo standardized brain MRI examinations at 0.55T, 1.5T, 3T, 5T, and 7T. MRI acquisitions include structural, diffusion, functional, and quantitative imaging sequences according to the study protocol. No therapeutic intervention will be administered
Regional Gray Matter Volume Across MRI Field Strengths
Regional gray matter volumes will be quantified from standardized structural MRI data and compared across 0.55T, 1.5T, 3T, 5T, and 7T MRI acquisitions.
Time frame: From enrollment through completion of all scheduled multi-field-strength MRI examinations, up to 12 months
Plan to share: No
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