A Phase 4 interventional study of ultrasound-guided Transversus Thoracis Muscle Plane Block in Postoperative Pain, sponsored by Hôpital du Valais. Completed at 1 site in Switzerland. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-06-15.
Sponsored by Hôpital du Valais · Phase 4, Interventional, and Treatment
Among 56 studies in Pain, Postoperative with a site in Switzerland — 12 open to participants now, 12 under way, none of them phase 3. Pain, Postoperative · Switzerland.
Among the 56 studies in Pain, Postoperative with a site in Switzerland, this one is the 19th largest by enrollment of the 47 interventional ones that give a count, is one of 4 that started in 2024, is one of 11 in phase 4, and was the 50th registered.
5,640 studies on the registry are indexed under Pain, Postoperative; 1,230 are open to participants now.
Browse Pain, Postoperative studies →12 of the 56 studies in Pain, Postoperative with a site in Switzerland are open now. Recruiting first, the newest first:
Andrea Saporito · Sites in Switzerland
Ages 18–80
Centre Hospitalier Universitaire Vaudois · Sites in Switzerland
Ages 18+
Centre Hospitalier Universitaire Vaudois · Sites in Switzerland
Ages 18+
Centre de Médecine Intégrative et Complémentaire (CEMIC) · Sites in Switzerland
Ages 18+
Helen Koechlin · Sites in Switzerland
Ages 8–18
A study can be open while its sites in Switzerland have not opened yet or have stopped. Only those recruiting at a site in Switzerland →
Of the 679 Pain, Postoperative studies recruiting now, 241 (35%) set no upper age limit and 328 (48%) stop at 75 or younger; 74 take children under 18; 128 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
56 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 2 3 · Phase 3 5 · Phase 4 11
First in 2004; this study’s year is marked. 4 started in 2024.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 100 is above the median of 75 across 4,821 interventional studies indexed under Pain, Postoperative.
Median enrollment 100 across the 47 interventional studies, 355 across the 9 observational. Of the 42 that completed or were terminated, 4 (10%) have results posted.
This tab as a report to print or save as PDF → With an account.
3 of 56 have an industry lead sponsor. The 10 most frequent:
Hôpital du Valais is the lead sponsor of 15 studies on the registry; 3 are open to participants now.
Hôpital du Valais has 1 study filed under Pain, Postoperative — fewer than ten, so there is no comparison to draw.
9 of the studies in Pain, Postoperative with a site in Switzerland that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT03490630Insel Gruppe AG, University Hospital BernPatient Reported Outcome After Bariatric Surgery | 2026-12 |
| NCT03489499Insel Gruppe AG, University Hospital BernGenetic Variants and Postoperative Pain | 2026-12 |
| NCT06107595Centre de Médecine Intégrative et Complémentaire (CEMIC)Conditioned Open Label Placebo for Postoperative Pain Management | 2026-12-31 |
| NCT05816174Helen KoechlinLongitudinal Study of Chronic Postsurgical Pain in Children and Adolescents | 2027-01 |
| NCT06317870Centre Hospitalier Universitaire VaudoisPericapsular Nerve Block Versus Intrathecal Morphine for Analgesia After Primary Hip Arthroplasty | 2027-01-01 |
Among the 56 studies in Pain, Postoperative with a site in Switzerland, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The goal of this randomized double blind study is to evaluate the analgesic efficacy of Transversus Thoracis Muscle Plane Block in patients undergoing cardiac surgery with median sternotomy.
one group of participants will receive multimodal analgesia plus ultrasound-guided Transversus Thoracis Muscle Plane Block with ropivacaine 0.5 % after induction of general anesthesia, the other group will receive multimodal analgesia without a bloc.
The investigators want to know if participants who receive the Transversus Thoracis Muscle Plane Block with ropivacaine have less pain than participants who do not receive a block.
Participants who undergo elective cardiac surgery with median sternotomy are eligible. They will receive general anaesthesia with multimodal analgesia as is standard in our institution. For study purposes participants will be randomized in a double blinded fashion to receive a Transversus Thoracis Muscle Plane Block with 30 mL of ropivacaine 0.5 %, or no block. As the block is carried out after induction of general anesthesia the participants will not know to which group they are assigned.
all blocks will be carried out after induction of general anesthesia, under full sterile precautions, and with ultrasound guidance. multimodal analgesia intra- and postoperatively is standardized and consists of: sufentanil, ketamine, dexmedetomidine, dexamethasone, paracetamol, metamizole, IV morphine in ICU.
The investigators aim for fast track surgery, i.e. extubation either in the operating room or in ICU within the first 6 postoperative hours.
the primary outcome is postoperative opioid consumption over the first 24 h postoperatively, secondary outcomes are pain scores and opioid-related side effects. all outcomes will be assessed by blinded investigators.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Participation in another study within the 30 days preceding and during the present study
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
The share of blood the heart’s main pumping chamber (the left ventricle) pushes out with each beat, measured by an echocardiogram (heart ultrasound) or a MUGA scan. About 50–70% is normal.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Hypersensitivity
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
LVEF (left ventricular ejection fraction)
The share of blood the heart’s main pumping chamber (the left ventricle) pushes out with each beat, measured by an echocardiogram (heart ultrasound) or a MUGA scan. About 50–70% is normal.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Multimodal analgesia + TTMP block with ropivacaine 0.5 %, 30 mL
Other: ultrasound-guided Transversus Thoracis Muscle Plane Block
Multimodal Analgesia without a block
block with ropivacaine 0.5 %, 30 mL
opioid consumption
cumulative intravenous morphine-equivalents
Time frame: 24 hours postoperatively
Postoperative pain 2 h
Numeric Rating Scale 0-10
Time frame: 2 hours postoperatively
Postoperative pain 6
Numeric Rating Scale 0-10
Time frame: 6 hours postoperatively
Postoperative pain 12
Numeric Rating Scale 0-10
Time frame: 12 hours postoperatively
Postoperative pain 24
Numeric Rating Scale 0-10
Time frame: 24 hours postoperatively
ICU length of stay
ICU length of stay
Time frame: 5 days
Plan to share: No
No publications or documents are linked to this record.
Ran from Aug 2024 to primary completion in May 2025, 9 months.
Of 531 non-industry phase 4 interventional studies under Pain, Postoperative, half reached primary completion within 16 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 32. This study's 9 months is below that.
Counting every sponsor, half of 541 studies reached it within 16 months; a quarter within 8 and three quarters within 32.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.
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Hôpital du Valais