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Status unknownNCT05217875Updated Feb 1, 2022

Prognostic of Dysfunctional Breathing in Long Covid: a Follow up Study

An observational study in COVID-19 and Dysfunctional Breathing, sponsored by Hôpital du Valais. Status unknown at 1 site in Switzerland. Open to participants aged 14 Years and older. Per ClinicalTrials.gov, last updated 2022-02-01.

Sponsored by Hôpital du Valais · Observational

The sponsor has not verified this record recently (last verified Dec 2021), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
50
Ages
14 Years and older
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 97 studies in COVID-19 with a site in Switzerland — 6 open to participants now, 10 under way, 1 of them phase 3. COVID-19 · Switzerland.

Planned enrollment
40th of 47
50 · median 425
Started
2021
with 24 others
Observational
47 of 97
1 open now
Registered
75th of 97
by date

Among the 97 studies in COVID-19 with a site in Switzerland, this one is the 40th largest by planned enrollment of the 47 observational ones that give a count, is one of 25 that started in 2021, is one of 47 observational ones, and was the 75th registered.

COVID-19

7,990 studies on the registry are indexed under COVID-19; 466 are open to participants now.

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Open to participants now

6 of the 97 studies in COVID-19 with a site in Switzerland are open now. Recruiting first, the newest first:

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All 6 open studies →

A study can be open while its sites in Switzerland have not opened yet or have stopped. Only those recruiting at a site in Switzerland →

Who these studies take

Of the 356 COVID-19 studies recruiting now, 207 (58%) set no upper age limit and 83 (23%) stop at 75 or younger; 91 take children under 18; 136 take healthy volunteers.

This study: 14 Years and older · all sexes · no healthy volunteers.

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02

Study summary

Dysfunctional breathing might participate to dyspnoea in long COVID-19. This study investigate the prognosis of patients diagnosed with dysfunctional breathing after SARS-CoV-2 infection in our center.

Read the detailed description

Dysfunctional breathing (DB) with or without hyperventilation syndrome (HVS) as diagnosed using cardiopulmonary exercise test (CPET) was recently demonstrated as an important physiopathological mechanism of persistent dyspnoea in long COVID patients [1]. DB is characterized by specific ventilation pattern on CPET accompanied by respiratory discomfort and/or dyspnea at exercise [2]. Most patients with DB will have undergone some sort a specific physiotherapy retraining [3]. However the prognostic and the predictors of persistence/resolution of DB after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are unknown.

The aim of the study is to determine the prognostic of patients diagnosed with DB after SARS-CoV-2 infection, as well as prognosis factors and predictors of persistence/resolution of DB during a prospective follow up visit.

03

Conditions studied

  • COVID-19
  • Dysfunctional Breathing

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Keywords

  • COVID-19
  • Dysfunctional breathing
  • Hyperventilation syndrome
  • Sighs
  • erratic breathing
04

Who can participate

Ages eligible
14 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

  • Patients of 14 years or more diagnosed with DB after COVID-19 using a combined approach of symptoms and CPET in the Hospitals of Sion, of Martigny or Rennaz

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • patients 14 years or more
  • diagnosis of DB after SARS-CoV-2 at our long covid clinic using a combined approach of symptoms and CPET analysis in the hospitals of Sion, Martigny or Rennaz
  • Inclusion between November 2020 and until the end of October 2021

Exclusion criteria

Exclusion Criteria:

  • Refusal to participate
  • comorbidities preventing the CPET or PFT to be carried out
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
50 participants (estimated)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Persistence/resolution of dysfunctional breathing at follow-up visit

    defined by persistence/resolution of dyspnea, as compared with patient's baseline (equivalent level of dyspnea as before COVID-19).

    Time frame: 6 to 9 monts from diagnosis

Secondary outcomes

  1. Change in ventilatory patterns (tidal volume [VT], breathing frequency [BF] at isowork as compared with baseline

    Time frame: 6 to 9 monts from diagnosis

  2. Dispersion of VT and BF during the CPET

    Time frame: 6 to 9 monts from diagnosis

  3. Change in ETCO2 and PaCO2

    Time frame: 6 to 9 monts from diagnosis

  4. Qualitative changes (increase/decrease/no change of DB pattern of CPET)

    Time frame: 6 to 9 monts from diagnosis

  5. Score HADS changes

    Time frame: 6 to 9 monts from diagnosis

  6. Score SF-36 changes

    Time frame: 6 to 9 monts from diagnosis

  7. Specific symptom scale changes

    Time frame: 6 to 9 monts from diagnosis

  8. Specific work capacity changes questions

    Time frame: 6 to 9 monts from diagnosis

  9. Post-COVID Functional Status (PCFS) changes

    Time frame: 6 to 9 monts from diagnosis

07

Study locations

1 of 1 sites recruiting
08

References and documents

Individual participant data

Plan to share: Undecided — Data upon reasonable requests

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Nov 2021 (actual). Primary completion is estimated for Jun 2022, 7 months after the start.

Of 1,640 non-industry observational studies under COVID-19, half reached primary completion within 14 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 30. This study's planned 7 months is below that.

Counting every sponsor, half of 1,774 studies reached it within 13 months; a quarter within 5 and three quarters within 29.

How these figures are worked out, and which studies are left out of them.

Registered
Jan 31, 2022
First posted
Feb 1, 2022
StartActual
Nov 1, 2021
Primary completionEst.
Jun 2022
CompletionEst.
Aug 2022
Last update
Feb 1, 2022
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Feb 1, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05217875
Lead sponsor
Hôpital du Valais
Responsible party
Sponsor
First posted
Feb 1, 2022
Start date
Nov 1, 2021
Primary completion
Jun 2022 (estimated)
Completion
Aug 2022 (estimated)
Last update
Feb 1, 2022

Study contacts

Pierre-Olivier v Bridevaux
Contact
pierre-olivier.bridevaux@hopitalvs.ch
+41792079069
Léon Genecand
Contact
leon.genecand@hcuge.ch
+41799372687

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Dec 2021. You cannot join it, but the record below documents what was studied.

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