An observational study in Postoperative Pain, Analgesia and Surgical Procedure, Operative, sponsored by Insel Gruppe AG, University Hospital Bern. Recruiting at 1 site in Switzerland. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-07.
Sponsored by Insel Gruppe AG, University Hospital Bern · Observational
Among 56 studies in Pain, Postoperative with a site in Switzerland — 12 open to participants now, 12 under way, none of them phase 3. Pain, Postoperative · Switzerland.
Among the 56 studies in Pain, Postoperative with a site in Switzerland, this one is one of 3 that started in 2011, is one of 9 observational ones, reaches primary completion later than 3 of the 11 other live ones, and was the 21st registered.
5,640 studies on the registry are indexed under Pain, Postoperative; 1,230 are open to participants now.
This study's planned enrollment of 5,000 is above the median of 102 across 683 observational studies indexed under Pain, Postoperative.
Browse Pain, Postoperative studies →12 of the 56 studies in Pain, Postoperative with a site in Switzerland are open now, in 1 country. Each count lists the studies.
Of the 679 Pain, Postoperative studies recruiting now, 241 (35%) set no upper age limit and 328 (48%) stop at 75 or younger; 74 take children under 18; 128 take healthy volunteers.
This study: 18 Years and older · all sexes · healthy volunteers too.
The full table on the hub →56 studies; the count open now beside each. This study's row is marked.
First in 2004; this study’s year is marked. 3 started in 2011.
Median enrollment 100 across the 47 interventional studies, 355 across the 9 observational. Of the 42 that completed or were terminated, 4 (10%) have results posted.
3 of 56 have an industry lead sponsor. The 10 most frequent:
Insel Gruppe AG, University Hospital Bern is the lead sponsor of 741 studies on the registry; 180 are open to participants now.
Insel Gruppe AG, University Hospital Bern has 4 studies filed under Pain, Postoperative — fewer than ten, so there is no comparison to draw.
9 of the studies in Pain, Postoperative with a site in Switzerland that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT03490630Insel Gruppe AG, University Hospital BernPatient Reported Outcome After Bariatric Surgery | 2026-12 |
| NCT03489499Insel Gruppe AG, University Hospital BernGenetic Variants and Postoperative Pain | 2026-12 |
| NCT06107595Centre de Médecine Intégrative et Complémentaire (CEMIC)Conditioned Open Label Placebo for Postoperative Pain Management | 2026-12-31 |
| NCT05816174Helen KoechlinLongitudinal Study of Chronic Postsurgical Pain in Children and Adolescents | 2027-01 |
| NCT06317870Centre Hospitalier Universitaire VaudoisPericapsular Nerve Block Versus Intrathecal Morphine for Analgesia After Primary Hip Arthroplasty | 2027-01-01 |
Among the 56 studies in Pain, Postoperative with a site in Switzerland, from their registry updates:
Prospective observational study to analyse patients' pain related outcome after surgery and ist association to genetic variants and non-genetic variables.
Background
Severe acute pain as well as long-lasting pain after surgery and pain-related interference of daily activities are frequent. Some risk factors for severe pain after surgery in adults have been described, e.g. younger age and pre-existing chronic pain. The question arises whether a specific genetic background is related to an unfavorable pain outcome.
Objective
The aim of this study is to investigate clinical and genetic variables and their possible association to severe acute postoperative pain, higher analgesic consumption and the development of chronic postsurgical pain.
Methods
Prospective observational study investigating clinical, patient related, surgery related and anesthesia related variables as well as genetic variants and their possible association to patients' pain related outcome after surgery.
Adult patients scheduled for elective surgery
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients undergoing elective surgery with anesthesia
Pain related impairment after surgery and its association to genetic and non-genetic variables
Measured by the International Pain Outcomes Questionnaire, the Brief Pain Inventory (BPI): Numeric rating scale for pain intensities, affective and physical interference; Composite score = pain interference total scores (PITS scale 0-10) resulting in no interference (PITS=0), mild interference (PITS \>0 and \<2), moderate interference (PITS 2-5) and severe interference (PITS \>5)
Time frame: day of surgery up to 1 year after surgery
Association of genetic and non-genetic variables with analgesic consumption
analgesic consumption
Time frame: day of surgery up to one year after surgery
Association of genetic and non-genetic variables with pain related outcome of patients 1 year after surgery
Measured by the Brief Pain Inventory (BPI) as pain interference total score PITS scale 0-10) resulting in no interference (PITS=0), mild interference (PITS \>0 and \<2), moderate interference (PITS 2-5) and severe interference (PITS \>5). Change of pain related impairment over time (before surgery, 2 days after surgery, 6 and 12 months after surgery)
Time frame: Up to one year after surgery
Association of genetic and non-genetic variables with chronic neuropathic postsurgical pain
Measured by a neuropathic pain questionnaire (number of neuropathic symptoms; at least three neuropathic symptoms are categorized as positive)
Time frame: up to one year after surgery
Started Jan 2011 (actual). Primary completion is estimated for Dec 2026, 191 months after the start.
Of 391 non-industry observational studies under Pain, Postoperative, half reached primary completion within 13 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 32. This study's planned 191 months is above that.
Counting every sponsor, half of 395 studies reached it within 13 months; a quarter within 5 and three quarters within 33.
How these figures are worked out, and which studies are left out of them.
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Insel Gruppe AG, University Hospital Bern →