An interventional study of Balance targeted exercises in Multiple Sclerosis, sponsored by University of Miami. Completed at 1 site in United States. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2025-01-31.
Sponsored by University of Miami · Not applicable, Interventional, and Treatment
The purpose of this study is to examine the effects of a postural adjustment, targeted training program on balance ability and postural responses anticipatory postural adjustments (APA) and compensatory postural adjustments (CPA) in individuals with MS
All participants participated in individual training program aimed at improving balance ability and postural adjustments. The training program and individual activities were based on previously published programs and motor learning principles, and consists of 18, 1-hour training sessions over six weeks (3 sessions/week). Training occurred in person 2 days a week (in person training) and at home (home exercise program) 1 day a week, for a total of 3 sessions per week. The duration of training sessions were 60 minutes per session for a total of 1,140 minutes of training. The exercise room temperature was centrally regulated (23.3 degrees C).
3,460 studies on the registry are indexed under Multiple Sclerosis; 661 are open to participants now.
This study's enrollment of 7 is below the median of 50 across 2,342 interventional studies indexed under Multiple Sclerosis.
Browse Multiple Sclerosis studies →University of Miami is the lead sponsor of 820 studies on the registry; 161 are open to participants now.
Of its 111 completed or terminated interventional studies of FDA-regulated products, 93 (84%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
participants in this group will receive the balance targeted exercises for up to 6 weeks
Behavioral: Balance targeted exercises
6-week exercise program, 3 sessions per week (2 sessions in person, 1 session of home exercises. Participants will receive a booklet with information about the home exercises and will receive a text message reminder), each session will last 60 minutes.
Change in balance ability as measured by the BESTest
The Balance Evaluation Systems Test (BESTest) will be used to measure balance ability. Items are scored from 0 (severe impairment) to 3 (no impairment), with a total score of 108. A higher score suggests better balance ability.
Time frame: Baseline, 6 weeks (post intervention)
Change in reaction time
Measure in seconds
Time frame: Baseline, 6 weeks (post intervention)
Change in movement velocity
Measure in degree per second
Time frame: Baseline, 6 weeks (post intervention)
Change in endpoint excursion percentage
measure of endpoint excursion in a percentage out of a100
Time frame: Baseline, 6 weeks (post intervention)
Change in directional control percentage
measure of directional control in a percentage out of a100
Time frame: Baseline, 6 weeks (post intervention)
Change in maximum excursion percentage
measure of maximum excursion in a percentage out of a100
Time frame: Baseline, 6 weeks (post intervention)
Change in muscle responses latency as measured by MCT
The Motor Control test (MCT) measures the subject's ability to generate a motor response latency to a sudden surface translation in a forward and backward direction at three different magnitudes (small, medium, and large). Latency: The time-lapse between the perturbation onset and the subject response for each limb. The latency is reported in milliseconds.
Time frame: Baseline, 6 weeks (post intervention)
Change in postural muscles responses latency as measured by Electromyography (EMG)
Postural muscles responses onset latency in seconds
Time frame: Baseline, 6 weeks (post intervention)
Change in APA as measured by microvolts
Postural muscles APA measured in microvolts
Time frame: Baseline, 6 weeks (post intervention)
Change in CPA as measured by microvolts
Postural muscles CPA in microvolts
Time frame: Baseline, 6 weeks (post intervention)
Change in balance confidence as measured by ABC
The Activities Specific Balance Confidence (ABC) scale is a self-report questionnaire of a subject's perceived level of balance confidence. It measures the subject's confidence in performing various ambulatory activities without falling. There are 16 items scored using a scale(0-100) with higher scores indicating more confidence in performing the tasks. A total score is reported by dividing the total ABC score by 16.
Time frame: Baseline, 6 weeks (post intervention)
Change in quality of life as measured by the MSQoL-54
Multiple Sclerosis Quality of Life - 54 (MSQoL-54) is a self-report questionnaire measuring subject perceived of quality of life. In total, it contains 54 items with a total score ranging from 0-100, with higher scores indicating a better quality of life
Time frame: Baseline, 6 weeks (post intervention)
Plan to share: No
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This study is completed, as verified in Jan 2025. You cannot join it, but the record below documents what was studied.
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University of Miami