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CompletedNCT06131970KONTINUEUpdated Feb 19, 2025

The Effectiveness of Continuous Ketamine Infusion (KONTINUE)

An observational study in Chronic Pain, sponsored by Centre Hospitalier Princesse Grace. Completed at 1 site in Monaco. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-02-19.

Sponsored by Centre Hospitalier Princesse Grace · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
80
Ages
18 Years and older
Sex
All
01

Study summary

There are different treatment for chronic pain. One possible treatment is intravenous infusions of ketamine.

Read the detailed description

Ketamine continuous intravenous infusion for 4 days in Hospital with 0.5 mg/kg/day associated with Magnesium Sulfate 1000mg/day.

Evaluation schedules will be performed at day 15,30 and 60.

02

Conditions studied

  • Chronic Pain

Keywords

  • Pain
  • Neuropathic pain
  • Chronic pain
  • Fibromyalgia
  • Musculoskeletal diseases
03

In context

Chronic Pain

3,227 studies on the registry are indexed under Chronic Pain; 729 are open to participants now.

This study's enrollment of 80 is below the median of 120 across 753 observational studies indexed under Chronic Pain.

Browse Chronic Pain studies →

Lead sponsor

Centre Hospitalier Princesse Grace is the lead sponsor of 19 studies on the registry; 4 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients with chronic pain treated with ketamine infusion

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Pain lasting for more than six months without to treatment

Exclusion criteria

Exclusion Criteria:

  • Inability to give consent
  • Severe psychiatric disorder
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
80 participants (actual)
Target follow-up
6 Months
Patient registry
Yes
06

What researchers measure

Primary outcomes

  1. Long-term effectiveness

    Improvement of the numerical scale - score 0 to 10 - 10 is the worst

    Time frame: 1 month

  2. Long-term effectiveness

    Clinical Global Impression of Change (CGI-C) - score 1 to 7 - 7 is the worst

    Time frame: 1 month

Secondary outcomes

  1. Pain relief

    Neuropathic Pain Symptom Inventory (NPSI) - score 0 to 10 - 10 is the worst

    Time frame: 15, 30, 60 days

  2. Variation of quality of life

    Short Form 12 health survey

    Time frame: 15, 30, 60 days

  3. Variation of quality of life

    Hospital Anxiety and Depression scale - score 0 to 21 - 21 is the worst

    Time frame: 15, 30, 60 days

07

Study locations

1 site
  • Centre Hospitalier Princesse Grace
    Monaco, 98000, Monaco
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 19, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06131970
Lead sponsor
Centre Hospitalier Princesse Grace
Responsible party
Sponsor
First posted
Nov 15, 2023
Start date
Feb 22, 2022
Primary completion
Aug 6, 2024
Completion
Aug 6, 2024
Last update
Feb 19, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.

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Discussion

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