An observational study in Knee Osteoarthritis, Total Knee Arthroplasty and Unicompartmental Knee Arthroplasty, sponsored by Peng Liu. Completed at 1 site in China. Open to participants aged 50 Years to 80 Years. Per ClinicalTrials.gov, last updated 2023-11-09.
Sponsored by Peng Liu · Observational
In recent years, pain management coordinated with enhanced recovery after surgery (ERAS) has been widely applied and rapidly developed in orthopedics, showing promising prospects. Since 2016, our hospital has used a series of continuously improved pain management schemes for patients with knee OA who underwent total knee arthroplasty (TKA), unicompartmental knee arthroplasty (UKA), and high tibial osteotomy (HTO). Here, we retrospectively analyze these patients' clinical data to compare the effects of different pain intervention measures during the perioperative period on postoperative pain, functional exercise, hospital stay, and prognosis of the three surgical methods in an attempt to provide a feasible solution for pain management of these patients.
We retrospectively analyzed the clinical data of patients with knee osteoarthritis (OA) who received surgical treatment to provide a feasible solution for perioperative pain management of these patients. The medical records of 714 patients with knee OA who had undergone total knee arthroplasty (n=551), unicompartmental knee arthroplasty (n=92) and high tibial osteotomy (n=71) were retrospectively analyzed and the cases were divided into Groups A, B, and C, according to the continuously optimized pain management. Clinical data including anesthesia grade, surgery time, functional exercise, hospital stay, pain, emotion, complications and prognosis were compared.
4,398 studies on the registry are indexed under Osteoarthritis; 582 are open to participants now.
This study's enrollment of 714 is above the median of 100 across 791 observational studies indexed under Osteoarthritis.
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The medical records of 714 patients (142 men, 40 women; mean age: 38.5 years; age range: 18-64 years) with moderate or severe knee OA who had undergone TKA (n=551), UKA (n=92), or HTO (n=71) in a group of joint surgery at Sichuan Provincial People's Hospital between March 2016 and February 2022 were retrospectively analyzed. Clinical data, including age, weight, height, anesthesia grade, surgery, and time, as well as continuously improved perioperative pain management measures, were recorded.
Exclusion Criteria:
Total knee arthroplasty
Procedure: Preoperative pain managment · Procedure: Intraoperative pain managment · Procedure: Postoperative pain managment
Unicompartmental knee arthroplasty
Procedure: Preoperative pain managment · Procedure: Intraoperative pain managment · Procedure: Postoperative pain managment
High tibial osteotomy
Procedure: Preoperative pain managment · Procedure: Intraoperative pain managment · Procedure: Postoperative pain managment
propaganda and education on pain; Preemptive analgesia with celecoxib (200 mg bid) 2 days before surgery
Squeeze to expel blood (tourniquet); Before skin suture, 20 mL 0.5% ropivacaine was given subcutaneously for local infiltration anesthesia;
The intravenous analgesia pump was placed until 48 h after surgery;On the second day after surgery, celecoxib (200 mg bid) was administered orally, and buprenorphine transdermal patch was applied externally until hospital discharge;FNB catheter was placed under the guidance of ultrasound and connected with an analgesic pump, the anesthesia lasted until 48 h after surgery ‡
visual analogue score (VAS)
visual analogue score (VAS)
Time frame: 24 hours after surgery
visual analogue score (VAS)
visual analogue score (VAS)
Time frame: 72 hours after surgery
Quadriceps muscle strength
Quadriceps muscle strength
Time frame: 24 hours after surgery
Quadriceps muscle strength
Quadriceps muscle strength
Time frame: 72 hours after surgery
Scope of activities to knee joint
Scope of activities to knee joint
Time frame: 24 hours after surgery
Scope of activities to knee joint
Scope of activities to knee joint
Time frame: 72 hours after surgery
Self-Rating Anxiety Scale (SAS)
Self-Rating Anxiety Scale (SAS)
Time frame: 24 hours after surgery
Self-Rating Anxiety Scale (SAS)
Self-Rating Anxiety Scale (SAS)
Time frame: 72 hours after surgery
Self-Rating Depression Scale (SDS)
Self-Rating Depression Scale (SDS)
Time frame: 24 hours after surgery
Self-Rating Depression Scale (SDS)
Self-Rating Depression Scale (SDS)
Time frame: 72 hours after surgery
This study is completed, as verified in Nov 2023. You cannot join it, but the record below documents what was studied.
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Peng Liu