A Phase 3 interventional study of Probiotic Blend Oral capsules and Corticosteroids for Local Oral Treatment in Oral Lichen Planus, sponsored by October 6 University. Recruiting at 1 site in Egypt. Open to participants aged 20 Years to 75 Years. Per ClinicalTrials.gov, last updated 2023-11-07.
Sponsored by October 6 University · Phase 3, Interventional, and Treatment
Among 35 studies in Lichen Planus, Oral with a site in Egypt — 5 open to participants now, 7 under way, 2 of them phase 3. Lichen Planus, Oral · Egypt.
Among the 35 studies in Lichen Planus, Oral with a site in Egypt, this one is the 13th largest by planned enrollment of the 23 interventional ones that give a count, is one of 10 that started in 2023, is one of 3 in phase 3, and was the 21st registered.
142 studies on the registry are indexed under Lichen Planus, Oral; 27 are open to participants now.
Browse Lichen Planus, Oral studies →5 of the 35 studies in Lichen Planus, Oral with a site in Egypt are open now. Recruiting first, the newest first:
British University In Egypt · Sites in Egypt
Ages 18+ · Healthy volunteers
Cairo University · Sites in Egypt
British University In Egypt · Sites in Egypt
Alexandria University · Sites in Egypt
Ages 18–65
A study can be open while its sites in Egypt have not opened yet or have stopped. Only those recruiting at a site in Egypt →
Of the 14 Lichen Planus, Oral studies recruiting now, 10 (71%) set no upper age limit and 2 (14%) stop at 75 or younger; 3 take children under 18; 3 take healthy volunteers.
This study: 20 Years to 75 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
35 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 5 · Phase 2 3 · Phase 3 3 · Phase 4 8
First in 2013; this study’s year is marked. 10 started in 2023.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 36 is close to the median of 39 across 101 interventional studies indexed under Lichen Planus, Oral.
Median enrollment 39 across the 23 interventional studies, 70 across the 12 observational. Of the 24 that completed or were terminated, 1 (4%) have results posted.
This tab as a report to print or save as PDF → With an account.
None of the 35 has an industry lead sponsor. The 10 most frequent:
October 6 University is the lead sponsor of 148 studies on the registry; 34 are open to participants now.
October 6 University has 2 studies filed under Lichen Planus, Oral — fewer than ten, so there is no comparison to draw.
3 of the studies in Lichen Planus, Oral with a site in Egypt that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07915570British University In EgyptSalivary IL-8 and Serum IL-6 as Biomarkers for Oral Potentially Malignant Disorders in Smokers and Never-Smokers | 2026-12-30 |
| NCT07846891Ain Shams UniversityLow Level Laser Therapy With Injectable Platelet Rich Fibrin in Management of Oral Lichen Planus | 2027-04-20 |
| NCT07910175Alexandria UniversityCurcumin-mediated Photodynamic Therapy Versus Photobiomodulation in the Treatment of Oral Erosive Lichen Planus | 2027-05-15 |
Add all 3 to your calendar (.ics) → With an account.
Among the 35 studies in Lichen Planus, Oral with a site in Egypt, from their registry updates:
This tab as a report to print or save as PDF → With an account.
Oral lichen planus patients who will meet inclusion criteria will be divided into 2 groups
-The intervention group (Group P): This group will be randomly allocated to take one capsule twice daily during meal time at morning and evening of probiotics complex obtained from Biovea for 4 -week study period. Moreover, patients in this group will be instructed to apply clobetasole propionate in orabase gel 2 times daily for 4 weeks. Patients will receive their supply of the gel and probiotics every 2 weeks. The control group (Group B): This group will be randomly allocated to apply clobetasol propionate in orabase gel 4 times daily after meal times and before sleeping for 4 weeks. At the 3rd week this group will be instructed to apply miconazole gel 4 times daily as a prophylaxis for two weeks.
Salivary sample collection: Unstimulated salivary sample was collected from all participants twice , once at baseline and another time after 4 weeks from the study period. Saliva was collected in graduated clear test tubes to be used in the evaluation of candidal counts before and after treatment .
Patient's visits was at baseline, 2 weeks and 4 weeks.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Immunosuppression
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Systemic probiotic capsules will be given twice daily in addition to topical application of topical clobetasol in orabase twice daily
Drug: Probiotic Blend Oral capsules · Drug: Corticosteroids for Local Oral Treatment
topical clobetasol in orabse application will be given 4 times daily ( 3 times after meals and once before bed time) prophylactic topical antifungal will be given in the fourth week to prevent candidal infection
Drug: Corticosteroids for Local Oral Treatment
probtiotic bend oral tablets from biovia will be adminestrated containing 4 strains ( twice daily) in addition to topical clobetasol application twice daily
topical clobetasol probionate in orabase application 4 times daily
Also known as: clobetasol probionate in orabase
size wound
thongprasom scale
Time frame: 0 , 2 weeks and 4 weeks
Pain in oral cavity
Numerical rating scale (0-10) 0= minimal pain 10 unbearable pain
Time frame: 0 , 2 weeks and 4 weeks
candidal load assessment
culturing technique in CFU unit
Time frame: 0 and 4 weeks
Plan to share: Yes
Supporting information: Study protocol
No publications or documents are linked to this record.
Started May 2023 (actual). Primary completion is estimated for Oct 2023, 5 months after the start.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.