An observational study in Major Depressive Disorder, sponsored by Xiaomei Shao. Completed at 1 site in China. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-03-15.
Sponsored by Xiaomei Shao · Observational
Evidence-based medicine suggests that acupuncture can improve major depressive disorder (MDD). However, the prevalent reliance on experiential acupoint selection lacks scientific underpinning. The investigators conducted a comparative study involving MDD patients and healthy subjects, employing modern techniques to discern biological specificity in MDD-related acupoints. Additionally, the investigators investigated potential correlations between acupoint biological specificity and MDD severity.
A final total of 134 eligible subjects were included. Among them, 50 healthy subjects were assigned to the healthy control (HC) group and 84 MDD participants were assigned to the MDD group.
4,845 studies on the registry are indexed under Depressive Disorder; 514 are open to participants now.
This study's enrollment of 184 is above the median of 150 across 653 observational studies indexed under Depressive Disorder.
Browse Depressive Disorder studies →Xiaomei Shao is the lead sponsor of 6 studies on the registry; 3 are open to participants now.
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The diagnostic criteria of MDD were based on criteria proposed by the International Classification of Diseases 10th Edition (ICD-10). Healthy control participants were determined by a recent depression screening report for confirming their mental health conditions.
Inclusion Criteria:
Inclusion criteria for the healthy control participants:
Inclusion criteria for the MDD participants:
Exclusion Criteria:
There were 50 healthy control participants in the HC group.
There were 84 MDD patients in the MDD group. 50 MDD subjects were enrolled at each acupoint for each test.
Temperature
Temperature of acupoints was measured by infrared thermography (IRT). IRT was not be performed on female subjects during their menstrual and ovulatory periods.
Time frame: Baseline
Pressure pain threshold
Pressure pain threshold was measured by pressure pain threshold gauge (PTG).
Time frame: Baseline
The Hamilton Depression Scale-17 (HAMD-17) Scores
The HAMD scale is the most commonly used in the clinical assessment of depression, including 17 items. The higher the score, the more severe the depression. 0-6 means no depressive symptoms, 7-16 means mild depression, 17-24 was divided into moderate depression, and more than 25 was divided into severe depression.
Time frame: Baseline
The Patient Health Questionaire-9 Items (PHQ -9)
The PHQ-9 scale has a total of 9 questions, each with a score of 0-3 (none: 0; a few days: 1; more than half of the time: 2; almost every day: 3), with a total score of 0-27.
Time frame: Baseline
The Self-Rating Depression Scale (SDS) Scores
The standard score is the total of all scores multiplied by 1.25 to the nearest whole number on this scale, which has 20 questions. A standard score below 50 is normal; 53-62 is mild depression; 63-72 is moderate depression; 72 or more is severe depression.
Time frame: Baseline
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Mar 2024. You cannot join it, but the record below documents what was studied.
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Xiaomei Shao