An observational study in Critical Illness and Mortality, sponsored by University of Cape Town. Completed at 1 site in Sudan. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-04-10.
Sponsored by University of Cape Town · Observational
In Africa, the prevalence of critical illness is likely to be higher due to a greater burden of disease, and the associated mortality higher due to limited resources. This is a prospective, observational study to rapidly establish the prevalence of critical illness in in-hospital adult patients in Africa, and the resources available to provide essential critical care (care that should be available to every patient in the world) and factors associated with mortality. Rapid dissemination of these findings may help mitigate mortality from critical illness in Africa. These points provide the rationale for the African Critical Illness Outcomes Study.
STUDY OBJECTIVES
The objectives of this study are to determine:
STUDY DESIGN
An African multi-centre prospective observational cohort study of adult (≥18 years) in-hospital patients. Patient follow up will be for a maximum of 7 days in-hospital.
The primary outcome is in-hospital mortality in adult hospital patients with and without critical illness in Africa.
The intention is to provide a representative sample of the mortality, the risk factors associated with mortality in adult patients with critical illness, and the resources available and interventions provided to treat critical illness in Africa. This study will run between September and November 2023.
PREPARATORY WORK
This study will be run by the African Perioperative Research Group (APORG), with a network of over 600 hospitals in more than 40 African countries which has successfully conducted the African Surgical Outcomes Study (ASOS), the ASOS-2 Trial, the African COVID-19 Critical Care Outcomes Study (ACCCOS) and the African Pediatric Surgical Outcomes Study (ASOS-PEDS).
IMPORTANCE OF THIS STUDY
To decrease the mortality associated with critical illness in Africa, it is important to rapidly establish the potential risk factors for mortality, and resources available to manage these patients. The APORG network has the capacity to provide these data timeously.
1,780 studies on the registry are indexed under Critical Illness; 442 are open to participants now.
This study's enrollment of 20,159 is above the median of 140 across 814 observational studies indexed under Critical Illness.
Browse Critical Illness studies →University of Cape Town is the lead sponsor of 116 studies on the registry; 14 are open to participants now.
Counted across the registry records on this site, refreshed daily.
All adult patients aged 18 years or over who have been admitted for inpatient care in any department or ward in participating hospitals.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
All adult inpatients in hospitals across Africa that are critically ill.
Presence of critical illness
The number of participants with critical illness.
Time frame: 7 days
In-hospital mortality (censored at 7-days)
The number of participants with in-hospital mortality (censored at 7-days)
Time frame: 7 days
Provision of essential emergency and critical care
To number of critically ill patients who receive essential emergency and critical care.
Time frame: 7 days
Length of hospital stay
The length of hospital stay for critically ill patients
Time frame: 7 days
Number of essential emergency and critical care resources available for care
The number of essential emergency and critical care resources available
Time frame: 7 days
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: Yes — A pragmatic and realistic dataset is fundamental to the success of the study. Data will be collected on paper on one-day in each hospital plus follow-up censored at 7 day.
Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Clinical study report
Time frame: Data will be available from the time of publication and for 10 years following publication.
Access criteria: Contributing researchers and collaborators
Data sharing details ↗ · www.asos.org.za
This study is completed, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.
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