An observational study in Weaning, Spontaneous Breathing Trial and Mechanical Ventilation, sponsored by Centre Hospitalier Universitaire, Amiens. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-15.
Sponsored by Centre Hospitalier Universitaire, Amiens · Observational
Among 29 studies in Sprains and Strains with a site in France — 7 open to participants now, 8 under way, none of them phase 3. Sprains and Strains · France.
Among the 29 studies in Sprains and Strains with a site in France, this one is the 12th largest by planned enrollment of the 16 observational ones that give a count, is one of 2 that started in 2023, is one of 16 observational ones, and was the 23rd registered.
246 studies on the registry are indexed under Sprains and Strains; 49 are open to participants now.
Browse Sprains and Strains studies →7 of the 29 studies in Sprains and Strains with a site in France are open now. Recruiting first, the newest first:
University Hospital, Angers · Sites in France
Ages 18+
Assistance Publique - Hôpitaux de Paris · Sites in France
Healthy volunteers
Centre Hospitalier Universitaire, Amiens · Sites in France
Ages 18+
Association Clinique Thérapeutique Infantile du val de Marne · Sites in France
Ages 1 days–17 yrs
Centre Hospitalier Universitaire de Saint Etienne · Sites in France
Ages 18–60
A study can be open while its sites in France have not opened yet or have stopped. Only those recruiting at a site in France →
Of the 36 Sprains and Strains studies recruiting now, 13 (36%) set no upper age limit and 20 (56%) stop at 75 or younger; 7 take children under 18; 9 take healthy volunteers.
This study: 18 Years and older · all sexes.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
29 studies; the count open now beside each. This study's row is marked.
First in 2001; this study’s year is marked. 2 started in 2023.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 60 is below the median of 101 across 79 observational studies indexed under Sprains and Strains.
Median enrollment 64 across the 13 interventional studies, 101 across the 16 observational. Of the 17 that completed or were terminated, 0 (0%) have results posted.
This tab as a report to print or save as PDF → With an account.
3 of 29 have an industry lead sponsor. The 10 most frequent:
Centre Hospitalier Universitaire, Amiens is the lead sponsor of 586 studies on the registry; 185 are open to participants now.
Centre Hospitalier Universitaire, Amiens has 4 studies filed under Sprains and Strains — fewer than ten, so there is no comparison to draw.
2 of the studies in Sprains and Strains with a site in France that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07028476University Hospital, AngersNew Care Pathway Using Automated Dynamic Laximetry | 2027-03 |
| NCT06009731Centre Hospitalier Universitaire, AmiensDiaphragmatic Speckle Tracking During Spontaneous Breathing Trial | 2027-06 |
Add all 2 to your calendar (.ics) → With an account.
Among the 29 studies in Sprains and Strains with a site in France, from their registry updates:
This tab as a report to print or save as PDF → With an account.
Currently, measurement of transdiaphragmatic pressure (Pdi) using oesophageal and gastric balloons is the gold standard for the assessment of diaphragmatic effort. This technique is relatively invasive and its interpretation may be complex. The diaphragmatic longitudinal strain (LSdi) and strain rate (LSRdi) might provide additional information in the assessment of diaphragmatic effort and movement during SBT, allowing early detection of diaphragmatic dysfunction. Patients will be monitored during a 30-120 minutes SBT consisting of no assistance on the ventilator using CPAP with a pressure level of 0 cmH2O. Parameters to evaluate diaphragm function will include diaphragmatic strain (LSdi and LSRdi), diaphragmatic thickening fraction (TFdi), and airway occlusion pressure (ΔP0.1 and ΔPocc). These parameters will be measured immediately before ('baseline') the SBT, as well as 2 minutes ('early' assessment), 15 ('intermediate' assessment) and 30 minutes ('late' assessment) after the beginning of the SBT.
Consecutive adult patients (≥18 years old) undergoing mechanical ventilation for at least 24h (regardless of the reason of intubation) and fulfilling criteria for an SBT will be included in the study. Briefly, to be eligible for an SBT, patients will have to (i) be able to trigger ventilator breaths with a reasonable level of assistance, (ii) lack of severe impairment in gas exchange, and (iii) not require significant hemodynamic support. Patients will be recruited by the study coordinator following completion of informed consent from the patient or legally authorized substitute decision maker.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
From a breathing test (spirometry): how much air you can blow out in the first second. Often given as a percentage of what is expected for your age, height and sex.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
COPD
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
FEV1
From a breathing test (spirometry): how much air you can blow out in the first second. Often given as a percentage of what is expected for your age, height and sex.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
changes of diaphragmatic longitudinal strain between baseline and during Spontaneous breathing trial
diaphragmatic longitudinal strain is LSdi Spontaneous breathing trial is SBT
Time frame: 7 days
changes of diaphragmatic longitudinal strain strain rate between baseline and during Spontaneous breathing trial
diaphragmatic longitudinal strain strain rate is LSRdi Spontaneous breathing trial is SBT
Time frame: 7 days
Plan to share: No
No publications or documents are linked to this record.
Started Jun 2023 (actual). Primary completion is estimated for Jun 2027, 48 months after the start.
Of 36 observational studies under Sprains and Strains, half reached primary completion within 25 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 36. This study's planned 48 months is above that.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Centre Hospitalier Universitaire, Amiens →