An interventional study of Maxillary and mandibular nerve block and Control in Analgesia, sponsored by Mansoura University. Recruiting at 1 site in Egypt. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-02-17.
Sponsored by Mansoura University · Not applicable, Interventional, and Prevention
Mandibular fractures are among the most common (60-70%) maxillofacial fractures observed in emergency rooms. In the closed reduction (non-surgical), the bone fragments are realigned manually or by using traction devices. The open reduction surgery of mandibular fractures should first ensure the restoration of the occlusion of the mandible to prevent postoperative malocclusion, followed by stabilization by means of rigid fixations such as plates, screws, and rigid intermaxillary blocks in order to minimise any nonunion, malunion, or delayed union of the fracture segments. These surgical procedures are associated with moderate postoperative pain, being the first 24 hours the most intense pain period. Maxillary and mandibular nerve blocks are performed in patients with refractory trigeminal neuralgia. However, there have been few studies evaluating the analgesic effects of these blocks for maxillofacial surgeries.
1,190 studies on the registry are indexed under Agnosia; 508 are open to participants now.
This study's planned enrollment of 60 is below the median of 78 across 1,024 interventional studies indexed under Agnosia.
Browse Agnosia studies →Mansoura University is the lead sponsor of 1,077 studies on the registry; 183 are open to participants now.
Of its 9 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
receive bilateral combined maxillary and mandibular nerve block. Three mL of 0.5% isobaric bupivacaine will be injected for each nerve block after negative aspiration of blood.
Procedure: Maxillary and mandibular nerve block
not receive any nerve block
Other: Control
receive bilateral combined maxillary and mandibular nerve block
not receive any nerve block
Total postoperative fentanyl rescue analgesic consumption
microgram
Time frame: first 24 hours postoperatively
Intraoperative heart rate (HR)
beats per minute
Time frame: each 15 minutes Intraoperative plus 1hour postoperatively and 2hours postoperatively
Intraoperative mean arterial pressure (MAP)
mmHg
Time frame: each 15 minutes Intraoperative plus 1hour postoperatively and 2hours postoperatively
10-cm visual analogue scale (VAS)
where 0 represented no pain, and 10 meant the worst possible pain
Time frame: at 0, 2, 4, 6, 8, 12, and 24 hours postoperatively
Postoperative analgesic duration
hours
Time frame: up to 24 hours (the time from ending of the nerve block till the first rescue morphine dose)
Patients' satisfaction about their analgesia
on a scale from 1 (poor), 2 (fair) to 3 (good)
Time frame: 24 hours postoperatively
Total postoperative diclofenac sodium consumption
mg
Time frame: 24 hours postoperatively
The total Intraoperative supplementary fentanyl
microgram
Time frame: during the intraoperative duration
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Mansoura University