An interventional study of Yellow Fever Vaccine in Yellow Fever, sponsored by Leiden University Medical Center. Recruiting at 1 site in Netherlands. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-06-13.
Sponsored by Leiden University Medical Center · Not applicable, Interventional, and Other
No antiviral treatment exists for yellow fever, only supportive care, and therefore we rely on prevention through vaccination. Although this vaccine is very effective, stockpiles are insufficient in outbreak situations and some people have a contraindication to be vaccinated. For those who are unprotected and at risk of yellow fever infection, treatment could be life saving.
No antiviral treatment exists for yellow fever, only supportive care, and therefore we rely on prevention through vaccination. Although this vaccine is very effective, stockpiles are insufficient in outbreak situations and some people have a contraindication to be vaccinated. For those who are unprotected and at risk of yellow fever infection, treatment could be life saving.
60 studies on the registry are indexed under Yellow Fever; 12 are open to participants now.
This study's planned enrollment of 30 is below the median of 110 across 48 interventional studies indexed under Yellow Fever.
Browse Yellow Fever studies →Leiden University Medical Center is the lead sponsor of 326 studies on the registry; 106 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
yellow fever vaccine arm (all participants receive the standard yellow fever vaccine (Stamaril)
Drug: Yellow Fever Vaccine
vaccination according to manufacturers manual (0.5mL subcutaneously in the arm)
Also known as: Stamaril (yellow fever vaccine)
yellow fever 17D in urine
yellow fever 17D in urine at sequential time points after vaccination
Time frame: within 30 days of the vaccination
peak of YF 17D viruria after vaccination
days after vaccination on which most participants have a positive yellow fever virus PCR on urine as material
Time frame: within 30 days of the vaccination
YF-17D viremia (in plasma) after vaccination
days after vaccination on which most participants have a positive yellow fever virus PCR on plasma as material
Time frame: within 14 days of the vaccination
Plan to share: No — research protocol and data will be shared upon request according to the institution's (LUMC) policy
No publications or documents are linked to this record.
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Leiden University Medical Center