An interventional study of Walking exercise + resistance training and Resistance training in Cognitive Function and Hypertension, sponsored by Beijing Sport University. Status unknown at 1 site in China. Open to female participants aged 55 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-06-12.
Sponsored by Beijing Sport University · Not applicable, Interventional, and Prevention
Brief Summary: The study was conducted in two parts, the first of which was carried out using a cross-sectional design approach to explore the relationship between cognitive function and autonomic function, brain function, inflammation and oxidative stress, vascular function, fitness levels, cardiorespiratory endurance and lipid metabolism. The second part uses a repeated measures design approach in a randomised controlled design to explore the effects of different types of exercise on cognitive decline in postmenopausal hypertensive women and their mechanisms of action.
Detailed Description: The study was conducted in 2 parts. Part I: was conducted using a cross-sectional design approach to explore the relationship between cognitive function and autonomic function, brain function, inflammation and oxidative stress, vascular function, fitness levels, cardiorespiratory endurance and lipid metabolism. Multiple linear regression was used to analyse the multiple linear relationships between changes in cognitive function and the above influences. Multiple logistic regression analysis was also used to analyse which of the above risk factors might be independent predictors of cognitive decline. Therefore, a combination of both regression analyses was used to further explore the multiple linear relationships between cognitive function and the aforementioned influencing factors, providing a viable causal and theoretical basis for the next exercise intervention.
The second part of the study is to test the viability of the vascular function theory. The "vascular function theory" refers to the use of exercise to improve aerobic capacity, improve blood circulation to the heart, and improve cerebrovascular function, which in turn improves cognitive function. Based on the above hypothesis, this study aims to investigate the possible effects of 12 weeks of different types of exercise on cognitive decline in post-menopausal women with HTN, and to lay the theoretical and practical foundation for the extension of the exercise intervention to other ages and populations.
6,689 studies on the registry are indexed under Hypertension; 965 are open to participants now.
This study's planned enrollment of 183 is above the median of 90 across 4,995 interventional studies indexed under Hypertension.
Browse Hypertension studies →Beijing Sport University is the lead sponsor of 51 studies on the registry; 9 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion criteria:
1 pre-menopausal, not falling under the above conditions 2 blood pressure not exceeding the above range 3 refractory hypertension and secondary hypertension 4 metabolic and cardiovascular diseases 5 unable to exercise for their own reasons 6 regular exercise (more than 6,000 steps per day) 7 poor lifestyle habits such as alcohol and smoking 8 suffering from cardiovascular disease risk classification of high or low
b.
Inclusion criteria for the negative control group:
Exclusion criteria:
Behavioral: Walking exercise + resistance training
Behavioral: Resistance training
Behavioral: Walking exercise
Behavioral: Health promotion
Behavioral: Health promotion
Walking exercise and resistance training for 12 weeks
Resistance training for 12 weeks
Walking exercise for 12 weeks
Health promotion for 12 weeks
MOCA score
The change of MOCA score. Montreal cognitive assessment (MoCA). The MoCA scale includes cognitive functions such as visuospatial and executive functions, naming, attention, language, abstraction, delayed recall and orientation, and evaluates the level of cognitive function from several cognitive dimensions. The MoCA has a total score of 30 questions, with 26 being normal and \<26 being cognitive decline.
Time frame: 12 weeks
Blood pressure
The change of blood pressure before and after intervention.
Time frame: 12 weeks
Quiet heart rate
The change of quiet heart rate before and after intervention.
Time frame: 12 weeks
Waist and hip circumference
The change of waist circumference and hip circumference before and after intervention.
Time frame: 12 weeks
Body fat percentage
The change of body fat percentage before and after intervention.
Time frame: 12 weeks
Lipid metabolism indicators
The change of lipid metabolism indicators before and after intervention. Lipid metabolism indicators include: total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C).
Time frame: 12 weeks
Cardiorespiratory endurance indicator
The change of cardiopulmonary endurance indicator before and after intervention. Cardiopulmonary endurance indicator: maximal oxygen uptake (VO2max) was determined using exercise cardiorespiratory testing system.
Time frame: 12 weeks
Serum interleukin-6 (IL-6)
The change of inflammation indicators before and after intervention.
Time frame: 12 weeks
High-sensitivity C-reactive protein (hs-CRP)
The change of inflammation indicators before and after intervention.
Time frame: 12 weeks
Vascular endothelial growth factor (VEGF)
The change of growth factor indicators before and after intervention.
Time frame: 12 weeks
Insulin-like growth factor(IGF-1)
The change of growth factor indicators before and after intervention.
Time frame: 12 weeks
Malondialdehyde (MDA)
The change of malondialdehyde (MDA) level before and after intervention.
Time frame: 12 weeks
Superoxide dismutase (SOD)
The change of superoxide dismutase (SOD) level before and after intervention.
Time frame: 12 weeks
Nitric oxide (NO)
The change of nitric oxide (NO) level before and after intervention.
Time frame: 12 weeks
Heart rate variability (HRV)
The change of heart rate variability (HRV) before and after intervention.
Time frame: 12 weeks
Mean flow rate (Vm) of middle cerebral artery and carotid artery
The change of middle cerebral artery mean flow rate and carotid artery mean flow rate before and after intervention.
Time frame: 12 weeks
Resistance index (RI) of middle cerebral artery and carotid artery
The change of middle cerebral artery resistance index and carotid artery resistance index before and after intervention.
Time frame: 12 weeks
Pulsatility index (PI) of middle cerebral artery and carotid artery
The change of middle cerebral artery pulsatility index and carotid artery pulsatility index before and after intervention.
Time frame: 12 weeks
Peak systolic velocity (PSV) and end-diastolic velocity (EDV) of carotid artery
The change of peak systolic velocity and end-diastolic velocity of carotid artery before and after intervention.
Time frame: 12 weeks
Vascular endothelial function indicator: Flow-mediated dilation (FMD)
The change of flow-mediated dilation before and after intervention.
Time frame: 12 weeks
Artery stiffness indicator: Carotid-femoral pulse artery stiffness (cfPWV).
The change of carotid-femoral pulse artery stiffness (cfPWV) before and after intervention.
Time frame: 12 weeks
This study is status unknown, as verified in Apr 2023. You cannot join it, but the record below documents what was studied.
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Beijing Sport University