An interventional study of Bupivacaine and Bupivacaine + Magnesium in Analgesia, sponsored by National Cancer Institute, Egypt. Recruiting at 1 site in Egypt. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-06-30.
Sponsored by National Cancer Institute, Egypt · Not applicable, Interventional, and Treatment
Postoperative pain management is considered an integral part of perioperative care in patients undergoing thoracotomy. In order to reduce these complications, multiple regional techniques have been developed for thoracotomy including Intercostal nerve block, Erectospinae plane block and serratus block. Multiple adjuvants have been used in regional analgesia including adrenaline,clonidine,magnesium sulphate,dexmedatomidine and opoids.
National Cancer Institute, Egypt is the lead sponsor of 133 studies on the registry; 29 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Blood cells that help blood clot. Too few raises the risk of bleeding and bruising. A usual adult range is about 150–400 × 10⁹/L (150,000–400,000 per µL); each lab has its own reference range.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Platelets
Blood cells that help blood clot. Too few raises the risk of bleeding and bruising. A usual adult range is about 150–400 × 10⁹/L (150,000–400,000 per µL); each lab has its own reference range.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients will receive ultrasound guided ESPB with 0.25% bupivacaine
Drug: Bupivacaine
Patients will receive ultrasound guided ESPB with 0.25% bupivacaine and magnesium
Drug: Bupivacaine + Magnesium
Patients will receive ultrasound guided ESPB with 0.25% bupivacaine and dexmedetomidine
Drug: Bupivacaine + Dexmedetomidine
Bupivacaine 0.25%
Drug pages: Bupivacaine · Magnesium
Bupivacaine 0.25% + Magnesium
Drug pages: Bupivacaine · Dexmedetomidine
Bupivacaine 0.25% + Dexmedetomidine
Total postoperative morphine consumption
Total dose of morphine needed postoperatively in the first 24 h
Time frame: First 24 hours postoperatively
Time to first postoperative rescue analgesia.
Time to first postoperative rescue analgesia.
Time frame: First 24 hours postoperatively
Plan to share: Undecided — Information is available upon reasonable request through contacting the corresponding investigator
No publications or documents are linked to this record.
Started May 2023 (actual). Primary completion is estimated for Nov 2026, 42 months after the start.
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Studies of the drugs tested here: Bupivacaine · Magnesium · Dexmedetomidine
Agnosia
National Cancer Institute, Egypt →