An interventional study of Single level serratus anterior plane block and Single level serratus anterior plane block with dexmedetomidine in Analgesia, sponsored by National Cancer Institute, Egypt. Recruiting at 1 site in Egypt. Open to female participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-06-30.
Sponsored by National Cancer Institute, Egypt · Not applicable, Interventional, and Prevention
This study aims to compare single level serratus block versus bilevel serratus block with and without dexmedetomidine in cancer patients undergoing modified radical mastectomy for breast cancer regarding pain control and possible side effects.
National Cancer Institute, Egypt is the lead sponsor of 133 studies on the registry; 29 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
the allocated patients will receive single injection serratus anterior plane block at the level of third rib with local anesthetics only
Procedure: Single level serratus anterior plane block
the allocated patients will receive single injection serratus anterior plane block at the level of third rib with local anesthetics and dexmedetomidine
Procedure: Single level serratus anterior plane block with dexmedetomidine
the allocated patients will receive injection serratus anterior plane block at 2 levels, the level of third rib and the level of the fifth rib with local anesthetics only
Procedure: Bilevel serratus anterior plane block
the allocated patients will receive injection serratus anterior plane block at 2 levels, the level of third rib and the level of the fifth rib with local anesthetics and dexmedetomidine
Procedure: Bilevel serratus anterior plane block with dexmedetomidine
Serratus anterior plane block with local anesthetics at the third rib
Serratus anterior plane block with local anesthetics and dexmedetomidine at the third rib
Serratus anterior plane block with local anesthetics at the third and fifth rib
Serratus anterior plane block with local anesthetics and dexmedetomidine at the third and fifth rib
First time to receive analgesia
first time to receive morphine analgesia in hours
Time frame: First 24 hours postoperatively
Total analgesic requisite
total amount of morphine consumption in the first 24 hours postoperatively in mg
Time frame: First 24 hours postoperatively
Pain scores
pain scores will be assessed using Visual Analogue Scale on a sale from 0 to 10 with 0 meanung no pain and 10 meaning severe pain
Time frame: First 24 hours postoperatively
Side effects
nausea and vomiting and hematoma at site of injection
Time frame: First 24 hours postoperatively
Perioperative heart rate values
heart rate values in the form of beat per minute in the perioperative period including preoperative, intraoperative and postoperative
Time frame: First 24 hours
Mean arterial blood pressure
Mean arterial blood pressure values in the form mmHg in the perioperative period including preoperative, intraoperative and postoperative
Time frame: First 24 hours
Plan to share: Undecided
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Agnosia
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