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RecruitingNCT05843630Updated May 6, 2023

Radiomic Modeling in Differentiating Uncomplicated From Complicated Acute Appendicitis

An observational study in Acute Appendicitis, sponsored by Kecheng Zhang. Recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2023-05-06.

Sponsored by Kecheng Zhang · Observational

From the registry’s dates

  • Primary completion was expected by Jun 2023, 3 years 4 months ago, but the record still lists the study as recruiting.
  • Started Jan 2023; still recruiting 3 years 9 months later.
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
250
Ages
18 Years and older
Sex
All
01

Study summary

Non-operative management (NOM) with antibiotics may be a safe alternative to surgery for uncomplicated appendicitis, but preoperative differentiation between uncomplicated and complicated appendicitis is challenging. The study aimed to develop a clinical-radiomics nomogram to distinguish uncomplicated from complicated appendicitis.

02

Conditions studied

  • Acute Appendicitis

Keywords

  • acute appendicitis
  • diagnosis
  • nomogram
03

In context

Appendicitis

412 studies on the registry are indexed under Appendicitis; 62 are open to participants now.

This study's planned enrollment of 250 is above the median of 200 across 150 observational studies indexed under Appendicitis.

Browse Appendicitis studies →

Lead sponsor

This is the only study on the registry with Kecheng Zhang as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Sampling method
Non-probability sample

Study population

All adults with pathologically diagnosed as acute appendicitis after appendectomy

Inclusion criteria

  • Pathologically diagnosed as acute appendicitis after appendectomy between January 2021 and December 2022.

Exclusion criteria

Exclusion Criteria:

  • age less than 18 years (no upper age limit);
  • without CT examination within a week before surgery;
  • difficult to outline the contours of the appendix due to inflammatory exudate;
  • lack of clinical information.
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
250 participants (estimated)
Patient registry
No

Groups and cohorts

  • Training cohort

    Model construction based on training cohort

    Diagnostic Test: without

  • Validation cohort 1

    Model validation in an independent validation cohort 1

    Diagnostic Test: without

  • Validation cohort 2

    Model validation in an independent validation cohort 2

    Diagnostic Test: without

Interventions

  • Diagnostic testwithout

    without

06

What researchers measure

Primary outcomes

  1. Accuracy of clinical-radiomic model for differentiating complicated from uncomplicated appendicitis

    ROC curve will be plotted and the area under ROC curve will be compared

    Time frame: January 2021 to December 2022

07

Study locations

1 of 1 sites recruiting
  • Chinese PLA General Hospital First Medical Center
    Beijing, China
    • Kecheng Zhang · Contact
    Recruiting
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 6, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05843630
Lead sponsor
Kecheng Zhang
Responsible party
Kecheng Zhang (Department of General Surgery, Chinese PLA General Hospital First Medical Center, Chinese PLA General Hospital) — Sponsor-investigator
First posted
May 6, 2023
Start date
Jan 3, 2023
Primary completion
Jun 3, 2023 (estimated)
Completion
Dec 3, 2023 (estimated)
Last update
May 6, 2023

Study contacts

LI LI
Contact
1192225348@qq.com
13210613213
Kecheng Zhang
principal investigator · Senior Department of General Surgery, Chinese PLA General Hospital

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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