An observational study in Echocardiography, Mechanical Circulatory Support and Myocardial Failure, sponsored by Semmelweis University Heart and Vascular Center. Not yet recruiting at 1 site in Hungary. Open to participants aged 18 Years to 99 Years. Per ClinicalTrials.gov, last updated 2024-04-18.
Sponsored by Semmelweis University Heart and Vascular Center · Observational
Investigation of the potential prognostic role of non-invasive myocardial work in patients receiving veno-arterial extracorporeal membrane oxygenation therapy.
The study aims to examine the prognostic role of non-invasive myocardial work in veno-arterial extracorporeal membrane oxygenation therapy patients. Subjects with cardiogenic shock regardless of etiology will be enrolled 48-72 hours after the initiation of mechanical circulatory support. It is hypothesized that non-invasive myocardial work may be an independent prognosticator of the outcome.
277 studies on the registry are indexed under Shock, Cardiogenic; 127 are open to participants now.
This study's planned enrollment of 100 is below the median of 200 across 142 observational studies indexed under Shock, Cardiogenic.
Browse Shock, Cardiogenic studies →Semmelweis University Heart and Vascular Center is the lead sponsor of 29 studies on the registry; 7 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Altogether 100 cardiogenic shock patients receiving veno-arterial extracorporeal membrane oxygenation therapy will be enrolled regardless the etiology. Both peripherially and centrally cannulated patients are eligible. Considering that the two populations are typically quite different in terms of indication for the therapy (ACS- or decompensated chronic heart failure-associated CS vs. cardiac surgery population), a balanced enrollment of the two methods will be facilitated. All LV venting options are eligible for enrollment, however, if utilized, the mode of LV unloading (central left atrial vent, Impella, transaortic LV pigtail catheter etc.) will also be collected.
Exclusion Criteria:
Cardiogenic shock patients from any cause receiving veno-arterial extracorporeal membrane oxygenation
Cardiovascular mortality, need for long-term mechanical circulatory support or heart transplantation
The total number of patients who die from cardiovascular cause, or require for transition to long-term mechanical circulatory support (LVAD/BiVAD), or heart transplantation
Time frame: 30 days
All-cause mortality
Death from any cause during the study period
Time frame: 30 days
Need for renal replacement therapy
The total number of patients who need for renal replacement therapy during intensive care
Time frame: 30 days
Successful weaning from mechanical ventilation
The total number of patients who can be successfully weaned from invasive mechanical ventilation
Time frame: 30 days
Discharge from intensive care unit
The total number of patients who are discharged from intensive care unit
Time frame: 30 days
Discharge from hospital
The total number of patients who are discharged from hospital
Time frame: 30 days
Ventilator-free days
Days spent without invasive mechanical ventilation
Time frame: 30 days
VA-ECMO-free days
Days spent without VA-ECMO support
Time frame: 30 days
Plan to share: Undecided
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This study is not yet recruiting, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.
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Semmelweis University Heart and Vascular Center