An interventional study of hypotension prediction index guidance in the Intraoperative Hypotension, sponsored by National Taiwan University Hospital. Recruiting at 1 site in Taiwan. Open to participants aged 20 Years to 80 Years. Per ClinicalTrials.gov, last updated 2024-09-19.
Sponsored by National Taiwan University Hospital · Not applicable, Interventional, and Prevention
We will investigate the effect of hypotension prediction index guidance on intraoperative hypotension and metabolomics in patients undergoing major upper gastrointestinal surgery
Intraoperative hypotension (IOH) has been shown to increase the risk of postoperative morbidity and mortality. The Hypotension prediction index (HPI) guidance is an algorithm that can predict impending hypotension, defined as mean arterial pressure below 65mmHg. Patients undergoing major upper abdominal surgery are at high risk of IOH occurrence, because the surgical procedures involve organ removal like intestinal resection and vessel or organ anastomoses or reconstruction, often associated with high blood loss. However, the effectivity of applying HPI for reducing the duration and severity of IOH and postoperative morbidity and mortality in short term within 30 days after surgery and long term within 1 year remains inconclusive.
Postoperative ileus (POI) generally defines absence of flatus within 72 hours after surgery. POI is known as the most important factor to slow patient recovery, increase postoperative morbidity and prolong the hospital stay following major upper abdominal surgery. Metabolomics can investigate the small molecule changes in response to certain stimulus, such as different environments. Metabolomics involves the comprehensive analysis of metabolites. In recent years, metabolomics has several applications in the early diagnosis and prevention of health and disease. However, the association between the POI occurrence and the metabolites in the presence and absence HPI guidance have not yet been investigated.
The proposed strategy and specific objectives of this 2 years project using a randomized controlled trial are as the follows:
1,003 studies on the registry are indexed under Hypotension; 173 are open to participants now.
This study's planned enrollment of 85 is close to the median of 80 across 675 interventional studies indexed under Hypotension.
Browse Hypotension studies →National Taiwan University Hospital is the lead sponsor of 2,563 studies on the registry; 569 are open to participants now.
Of its 11 completed or terminated interventional studies of FDA-regulated products, 2 (18%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
patients with hypotension prediction index guidance
Procedure: hypotension prediction index guidance
using hypotension prediction index guidance to prevent intraoperative hypotension
time weighted average mean arterial pressure less than 65 mmHg
the severity and duration of hypotension during surgery
Time frame: surgery
Plan to share: No — due to ethical issue
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National Taiwan University Hospital