An interventional study of Triflow and Control in Long COVID, sponsored by European University Cyprus. Active, not recruiting at 1 site in Cyprus. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-08-14.
Sponsored by European University Cyprus · Not applicable, Interventional, and Treatment
The aim of this clinical trial is to investigate the efficacy of Triflow in the rehabilitation of patients with long covid syndrome hospitalised in a rehabilitation center. Participants will be divided into 2 groups and follow their exercise regime until the day they are discharged from the rehabilitation center. The intervention group will participate in a rehabilitation program which includes upper and lower limbs exercises, cycle ergometer, walking and the use of triflow. The control group will participate in the same program but without the Triflow.
Randomised controlled trial with 2 groups:Triflow and exercises (intervention) and exercises (control)
Exercises:Exercises in the bed, chair and standing with/without weights, walking, cycle ergometer, treadmill.
Triflow: 10 breaths in and 10 breaths out.
Both groups will have 1 physiotherapy session per day for 6 days per week from admission to discharge.
Sample size:The sample size is 70. We took into consideration the efficacy of completing the recruitment of patients in time. There few published studies with the use of Triflow as their primary intervention with smaller sample sizes.
Population: Adults with long covid hospitalised in the rehabilitation center
Statistical Analysis: will be done through IBM SPSS Statistics 20 and the level of statistical significance will be (p \< 0.05).
From the literature and international guidelines, physiotherapy should be offered to people hospitalized with long-COVID, without any serious risks and offering significant benefit.
604 studies on the registry are indexed under Post-Acute COVID-19 Syndrome; 201 are open to participants now.
This study's planned enrollment of 70 is above the median of 60 across 416 interventional studies indexed under Post-Acute COVID-19 Syndrome.
Browse Post-Acute COVID-19 Syndrome studies →European University Cyprus is the lead sponsor of 15 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Use of Triflow device and exercise regime
Other: Triflow
Only exercise regime
Other: Control
Triflow
Also known as: Triflow and exercise regime
Exercise
Also known as: Exercise regime
Barthel Index
Measures performance in activities of daily living (eg.stairs, dressing/undressing, washing,eating). Score from 0 to 100, where 0 indicates total dependence and 100 total independence with activities of daily living.
Time frame: on admission day
Barthel Index
Measures performance in activities of daily living (eg.stairs, dressing/undressing, washing,eating). Score from 0 to 100, where 0 indicates total dependence and 100 total independence with activities of daily living.
Time frame: on discharge day
Dyspnoea (Medical Research Council Dyspnoea Scale)
Assess dyspnoea via MRC dyspnoea scale. The participants grade their dyspnoea on a scale of 1 to 5. The bigger the number, the worse their dyspnoea is
Time frame: on admission day
Dyspnoea (Medical Research Council Dyspnoea Scale)
Assess dyspnoea via MRC dyspnoea scale. The participants grade their dyspnoea on a scale of 1 to 5. The bigger the number, the worse their dyspnoea is
Time frame: on discharge day
Peak Flow Meter
Assess the respiratory function via peak flow meter. The participants will take a deep breath and blow the air out into the peak flow meter. The higher the score the better their respiratory function is
Time frame: on admission day
Peak Flow Meter
Assess the respiratory function via peak flow meter. The participants will take a deep breath and blow the air out into the peak flow meter. The higher the score the better their respiratory function is
Time frame: on discharge day
Number of hospitalisation days
Number of days participants stay in the rehabilitation center
Time frame: on discharge day
Muscle strength (Hand Grip)
Assess muscle strength for the upper extremities via hand-held dynamometer
Time frame: on admission day
Muscle strength (Hand Grip)
Assess muscle strength for the upper extremities via hand-held dynamometer
Time frame: on discharge day
Muscle strength and endurance (30 seconds Sit to stand)
Assess muscle strength for the lower extremities and endurance via 30 seconds sit to stand. The participants will have to stand up from a chair without using their arms as many times as they can in 30 seconds. The more times the better their muscle strength and endurance
Time frame: on admission day
Muscle strength and endurance (30 seconds Sit to stand)
Assess muscle strength for the lower extremities and endurance via 30 seconds sit to stand. The participants will have to stand up from a chair without using their arms as many times as they can in 30 seconds. The more times the better their muscle strength and endurance
Time frame: on discharge day
Balance (Berg Balance)
Assess via Berg Balance Questionnaire, a total of 14 items that asess balance. from 0 to 56, the higher the score the better balance a person has and has a smaller risk for falls.
Time frame: on admission day
Balance (Berg Balance)
Assess via Berg Balance Questionnaire, a total of 14 items that asess balance. from 0 to 56, the higher the score the better balance a person has and has a smaller risk for falls.
Time frame: on discharge day
Cardiorespiratory fitness (Six minutes walking test)
Assess the cardiorespiratory fitness via 6 minutes walking test. The participants have to walk for 6 mins independently and the distance they cover is measured. The bigger the distance the better cardiorespiratory fitness.
Time frame: on admission day
Cardiorespiratory fitness (Six minutes walking test)
Assess the cardiorespiratory fitness via 6 minutes walking test. The participants have to walk for 6 mins independently and the distance they cover is measured. The bigger the distance the better cardiorespiratory fitness.
Time frame: on discharge day
Quality of life (EQ-5D-5L)
Assess via EQ-5D-5L questionnaire, it has 6 components (movement,self-care, everyday activities, pain/discomfort, stress/depression, and a scale from 0 to 100 for participants to score how they perceive their health on the day( 0 indicates worst heath and 100 best health)
Time frame: on admission day
Quality of life (EQ-5D-5L)
Assess via EQ-5D-5L questionnaire, it has 6 components (movement,self-care, everyday activities, pain/discomfort, stress/depression, and a scale from 0 to 100 for participants to score how they perceive their health on the day( 0 indicates worst heath and 100 best health)
Time frame: on discharge day
Fatigue (Multidimensional fatigue inventory)
Assess the feeling of fatigue via Multidimensional fatigue inventory. it has 20 questions with a scale from 1(yes that is true) to 5 (no that is not true)
Time frame: on admission day
Fatigue (Multidimensional fatigue inventory)
Assess the feeling of fatigue via Multidimensional fatigue inventory. it has 20 questions with a scale from 1(yes that is true) to 5 (no that is not true)
Time frame: on discharge day
Timed up and Go
Assesses mobility and fall risk. Participants have to walk 3m, the shorter the time the better their mobility
Time frame: on admission day
Timed up and Go
Assesses mobility and fall risk. Participants have to walk 3m, the shorter the time the better their mobility
Time frame: on discharge day
Plan to share: No
This study is active, not recruiting, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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Post-Acute COVID-19 Syndrome →
European University Cyprus