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RecruitingNCT05810571Updated Oct 26, 2024

Comparison of Postoperative Analgesic Efficacy of the Erector Spina Plane Block and Quadratus Lumborum Block in Open Nephrectomy: a Prospective Randomized Clinical Study

An interventional study of preoperative remifentanil consumption and postopeartive controlled anlagesia with morphine in Renal Cell Carcinoma, sponsored by Kocaeli University. Recruiting at 2 sites in Turkey. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2024-10-26.

Sponsored by Kocaeli University · Not applicable, Interventional, and Diagnostic

From the registry’s dates

  • Started Oct 2024; still recruiting 1 year 11 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
18 Years to 85 Years
Sex
All
01

Study summary

patients who will undergo elective open nephrectomy will be divided into three groups; the control (PCA), the erector spina plane block, and the quadratus lumborum block. After standard anesthesia induction and monitorization then Bispectral index monitoring will be applied to all patients. Anesthesia will be maintained using sevoflurane in a mixture of oxygen and air. Continuous remifentanil infusion will be used for analgesia. Then patient's numeric rating scales and morphine pca consumptions will be recorded for one day.

Read the detailed description

patients who will undergo elective open nephrectomy will be divided into three groups; the control (PCA), the erector spina plane block and the quadratus lumborum block. After standard anesthesia induction and monitorization then Bispectral index monitoring will be applied to all patients. Anesthesia will be maintained using sevoflurane in a mixture of oxygen and air. Continious remifentanil infusion will be used for analgesia. Then patient's numeric rating scales and morphine pca consumptions will be recorded for one day.

02

Conditions studied

  • Renal Cell Carcinoma

Keywords

  • erector spina plane block
  • quadratus lumborum block
  • patient controlled analgesia
  • nephrectomy
  • analgesia
03

In context

Carcinoma, Renal Cell

1,965 studies on the registry are indexed under Carcinoma, Renal Cell; 378 are open to participants now.

This study's planned enrollment of 60 is above the median of 42 across 1,480 interventional studies indexed under Carcinoma, Renal Cell.

Browse Carcinoma, Renal Cell studies →

Lead sponsor

Kocaeli University is the lead sponsor of 210 studies on the registry; 38 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 85 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • ASA 1-3
  • open nephrectomy elective patients
  • BMI\<35

Exclusion criteria

Exclusion Criteria:

  • ASA 4-5-6
  • Laparoscopic nephrectomy
  • infection at the block side
  • coagulation disorder
  • BMI>35
05

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
60 participants (estimated)

Study arms

  • Placebo comparator
    patient controlled analgesia

    this group of patients received no block, received only postoperative patient-controlled analgesia with morphine

    Procedure: preoperative remifentanil consumption · Procedure: postopeartive controlled anlagesia with morphine

  • Active comparator
    erector spina plane block

    this group of patients received erector spina plane block preoperatively, received only postoperative patient-controlled analgesia with morphine

    Procedure: preoperative remifentanil consumption · Procedure: postopeartive controlled anlagesia with morphine

  • Active comparator
    quadratus lumborum block

    this group of patients received erector spina plane block preoperatively, received only postoperative patient-controlled analgesia with morphine

    Procedure: preoperative remifentanil consumption · Procedure: postopeartive controlled anlagesia with morphine

Interventions

  • Procedurepreoperative remifentanil consumption

    continuous remifentanil infusion will applied for peroperative analgesia

  • Procedurepostopeartive controlled anlagesia with morphine

    postoperative morphine patient controlled analgesia will be applied for postoperative analgesia

06

What researchers measure

Primary outcomes

  1. postoperative morphine consumption

    amount of postoperative morphine use of the patient's

    Time frame: 24 hour postoperatively

Secondary outcomes

  1. peroperative remifentanil consumptions

    amount of remifentanil use of the patient's

    Time frame: 4 hour preoperatively

  2. numeric rating scale

    numeric rating scores of the patient's postoepartively

    Time frame: 24 hour postoperatively

07

Study locations

1 of 2 sites recruiting
  • Kocaeli University Medical Faculty
    İzmit, 41100, Turkey
    Recruiting
  • Kocaeli University Medical Faculty
    Kocaeli, Turkey
    Active, not recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 26, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05810571
Lead sponsor
Kocaeli University
Responsible party
Zehra Ipek ARSLAN (Professor, Kocaeli University) — Principal investigator
First posted
Apr 12, 2023
Start date
Oct 24, 2024
Primary completion
Jan 3, 2027 (estimated)
Completion
Jan 3, 2027 (estimated)
Last update
Oct 26, 2024

Study contacts

zehra ipek Arslan AYDIN, Professor
Contact
zehraipek48@gmail.com
00905325011339
Zehra ipek Arslan, Professor
Contact
zehraipek48@gmail.com
00905325011339

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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