An interventional study of Splenda drink and Maltodextrin drink in Appetitive Behavior and Glucose Metabolism Disorders, sponsored by King's College London. Completed at 1 site in United Kingdom. Open to participants aged 18 Years to 64 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-04-12.
Sponsored by King's College London · Not applicable, Interventional, and Basic science
This study investigates the effects of Splenda, an artificial sweetener powder containing sucralose, on post-prandial blood glucose levels, appetite scores and subsequent energy intake.
Participants are randomly assigned to receive either the placebo drink (4.5g maltodextrin dissolved in 250ml water) or the Splenda drink (4.5g Splenda dissolved in 250ml water) taken alongside a high calorie breakfast.
Blood glucose measurements will be obtained through finger-pricking and appetite will be measured using self-reported visual analogue scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after breakfast. Energy intake will be measured using a 24 hour food diary.
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This study's enrollment of 51 is close to the median of 48 across 670 interventional studies indexed under Metabolic Diseases.
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Exclusion Criteria:
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Drink containing 4.5g Splenda dissolved on 250ml water.
Dietary Supplement: Splenda drink · Dietary Supplement: High carbohydrate breakfast
Drink containing 4.5g maltodextrin dissolved on 250ml water.
Dietary Supplement: Maltodextrin drink · Dietary Supplement: High carbohydrate breakfast
4.5g Splenda containing 1% sucralose, 95% maltodextrin, dissolved in 250ml water and consumed with a high carbohydrate breakfast.
4.5g maltodextrin dissolved in 250ml water and consumed with a high carbohydrate breakfast.
Meal consisting of 30g cereal with 100ml skimmed milk, 1.5 slices white toast with 12g margarine, providing 386kcal, 61.4g carbohydrate, 10.4g protein and 10.1g fat.
Change in blood glucose
Capillary blood glucose from fingerprick and measured using glucose monitor
Time frame: -5 to 180 minutes (measured from baseline up to 90min every 15min and from 90-180min every 30min)
Change in appetite
Feelings of hunger, desire to eat, fullness and alertness measured using Visual Analogue Scale (VAS)
Time frame: -5 to 180 minutes (measured from baseline up to 90min every 15min and from 90-180min every 30min)
24 hour energy intake
Food intake over the 24 hours of the study day using a 24 hour food diary entered into dietary analysis software
Time frame: 0 - 24 hours
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Mar 2023. You cannot join it, but the record below documents what was studied.
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King's College London